A method allowing the selective oxygen labelling of aliphatic polyacids, for example, succinic and glutaric acids, is reported. This process is based on the hydrolysis of a 3-alkyl-4-nitroisoxazol-5-yl group by Na18OH and affords the products in high yields. The same procedure was applied for the preparation of labelled aliphatic carboxylic acids.
Preparation of mono-labelled aliphatic polyacids via isoxazole derivatives / M. F. A. Adamo; P. Sarti-Fantoni; S. Chimichi; A. Sandrelli. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 51:(2010), pp. 6310-6312. [10.1016/j.tetlet.2010.09.113]
Preparation of mono-labelled aliphatic polyacids via isoxazole derivatives
CHIMICHI, STEFANO;
2010
Abstract
A method allowing the selective oxygen labelling of aliphatic polyacids, for example, succinic and glutaric acids, is reported. This process is based on the hydrolysis of a 3-alkyl-4-nitroisoxazol-5-yl group by Na18OH and affords the products in high yields. The same procedure was applied for the preparation of labelled aliphatic carboxylic acids.
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