Abstract Using traditional echocardiography, the diagnosis of cardiac amyloidosis (CA) is often only possible in advanced stage when recommended therapies may have adverse effects. The aim of our study was to evaluate whether additional information can be derived from Tissue and strain Doppler imaging (TDI and SDI). Forty patients with systemic amyloidosis and 24 healthy subjects underwent traditional, tissue and strain Doppler echocardiography. Patients were classified having CA if mean wall thickness (mT), was half of the sum septum and posterior wall thickness, was 12 mm. The following parameters were evaluated: peak early diastolic velocity (Em) as index of ventricular relaxation, mitral E-wave to Em ratio (E/Em) as index of left ventricular (LV) filling pressure and mean LV strain peak curves (mSt) as global long-axis contraction index. In non cardiac amyloidosis (NCA), both Em and mSt were lower than in age matched controls (p50.01, p50.05, respectively) and higher than in CA (p50.01 and p50.01, respectively). Both Em and mSt were related to mT (p50.001). A significant (p50.01) nonlinear relation was observed between plasma terminal of pro B-natriuretic peptide and mT, Em, E/Em and mSt. TDI and SDI are able to detect amyloid myocardial involvement in such an early stage that cannot be evidenced by using traditional echocardiography.

Tissue Doppler and strain imaging: a new tool for early detection of cardiac amyloidosis / Porciani MC; Lilli A; Perfetto F; Cappelli F; Massimiliano Rao C; Del Pace S; Ciaccheri M; Castelli G; Tarquini R; Romagnani L; Pastorini T; Padeletti L; Bergesio F.. - In: AMYLOID. - ISSN 1350-6129. - ELETTRONICO. - 16:(2009), pp. 63-70.

Tissue Doppler and strain imaging: a new tool for early detection of cardiac amyloidosis.

PERFETTO, FEDERICO;Cappelli F;TARQUINI, ROBERTO;PADELETTI, LUIGI;
2009

Abstract

Abstract Using traditional echocardiography, the diagnosis of cardiac amyloidosis (CA) is often only possible in advanced stage when recommended therapies may have adverse effects. The aim of our study was to evaluate whether additional information can be derived from Tissue and strain Doppler imaging (TDI and SDI). Forty patients with systemic amyloidosis and 24 healthy subjects underwent traditional, tissue and strain Doppler echocardiography. Patients were classified having CA if mean wall thickness (mT), was half of the sum septum and posterior wall thickness, was 12 mm. The following parameters were evaluated: peak early diastolic velocity (Em) as index of ventricular relaxation, mitral E-wave to Em ratio (E/Em) as index of left ventricular (LV) filling pressure and mean LV strain peak curves (mSt) as global long-axis contraction index. In non cardiac amyloidosis (NCA), both Em and mSt were lower than in age matched controls (p50.01, p50.05, respectively) and higher than in CA (p50.01 and p50.01, respectively). Both Em and mSt were related to mT (p50.001). A significant (p50.01) nonlinear relation was observed between plasma terminal of pro B-natriuretic peptide and mT, Em, E/Em and mSt. TDI and SDI are able to detect amyloid myocardial involvement in such an early stage that cannot be evidenced by using traditional echocardiography.
2009
16
63
70
Porciani MC; Lilli A; Perfetto F; Cappelli F; Massimiliano Rao C; Del Pace S; Ciaccheri M; Castelli G; Tarquini R; Romagnani L; Pastorini T; Padeletti L; Bergesio F.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/559101
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