This study was prospectively conducted in 11 haematology divisions over a 2-year period to evaluate the efficacy of caspofungin in 24 neutropenic patients with haematological malignancies (HM) and candidaemia. These patients had received chemotherapy for HM and were neutropenic (PNN < 0.5 · 109/L) for a median of 12 days (2–41) before candidaemia. The patients received caspofungin for a median duration of 12 days (range 6–26), obtaining a favourable overall response of 58%. At 30 days, 11 patients had died (46%); candidaemia was responsible for mortality in six patients (25%). These results suggest that treatment of candidaemia with caspofungin in neutropenic HM was efficacious, as it is in non-haematological subgroups.

Caspofungin for the treatment of candidaemia in patients with haematological malignancies / L.Pagano ; L.Fianchi ; R. Fanci ; A. Candoni ; M. Caira ; B.Posteraro ; M.Morselli ; CG.Valentini ; G. Farina ; ME.Mitra ; M. Offidani ; M.Sanguinetti ; ME.Tosti ; A. Nosari ; G.Leone ; P.Viale. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - STAMPA. - 16:(2010), pp. 298-301.

Caspofungin for the treatment of candidaemia in patients with haematological malignancies.

FANCI, ROSA;
2010

Abstract

This study was prospectively conducted in 11 haematology divisions over a 2-year period to evaluate the efficacy of caspofungin in 24 neutropenic patients with haematological malignancies (HM) and candidaemia. These patients had received chemotherapy for HM and were neutropenic (PNN < 0.5 · 109/L) for a median of 12 days (2–41) before candidaemia. The patients received caspofungin for a median duration of 12 days (range 6–26), obtaining a favourable overall response of 58%. At 30 days, 11 patients had died (46%); candidaemia was responsible for mortality in six patients (25%). These results suggest that treatment of candidaemia with caspofungin in neutropenic HM was efficacious, as it is in non-haematological subgroups.
2010
16
298
301
L.Pagano ; L.Fianchi ; R. Fanci ; A. Candoni ; M. Caira ; B.Posteraro ; M.Morselli ; CG.Valentini ; G. Farina ; ME.Mitra ; M. Offidani ; M.Sanguinetti ; ME.Tosti ; A. Nosari ; G.Leone ; P.Viale
File in questo prodotto:
File Dimensione Formato  
caspofungin.pdf

Accesso chiuso

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Tutti i diritti riservati
Dimensione 46.45 kB
Formato Adobe PDF
46.45 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/628289
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact