We aimed to identify specific polymorphisms of genes encoding for superoxide dismutase (SOD) 1 (cytoplasmic Cu/ZnSOD), SOD2 (mitochondrial MnSOD), SOD3 (extracellular Cu/ZnSOD), and CAT in a cohort of preterm infants and correlate their presence to the development of RDS, BPD, IVH and ROP. We carried out a retrospective study to evaluate the allele frequency and the genotype distribution of polymorphisms of SODs and CAT in a population of preterm neonates (n=152) with a gestational age ≤28 weeks according to the presence or absence of RDS, BPD, IVH, and ROP. Moreover, we evaluated through the haplotype reconstruction analysis whether combinations of the selected polymorphisms are related to the occurrence of RDS, BPD, IVH and ROP. We found that rs8192287 SOD3 polymorphism is an independent protective factor for all grade IVH, while rs4880 and rs5746136 SOD2 polymorphisms are associated with a lower gestational age (rs4880, rs5746136) and birth weight (rs4880). Haplotypes reconstruction showed that SOD1 (GG) decreased the risk of RDS, IVH, and ROP; SOD2 (GT) increased the risk of BPD and decreased the risk of RDS, IVH, and ROP; SOD3 (TGC) decreased the risk of BPD and IVH; and 4) CAT (CTC) decreased the risk of RDS. Conclusions: the rs8192287 SOD3 polymorphism is per se an independent predictor of a decreased risk of developing IVH. Different SOD2 polymorphisms are associated per se with a lower gestational age and/or birth weight, and haplotypes of SOD1, SOD3, and CAT genes may be independent protecting or risk markers for prematurity complications.
Genetic polymorphisms of antioxidant enzymes as risk factors for oxidative stress-associated complications in preterm infants / B. Giusti;A. Vestrini; C. Poggi; A. Magi; E. Pasquini; R. Abbate; C. Dani. - In: FREE RADICAL RESEARCH. - ISSN 1071-5762. - STAMPA. - 46:(2012), pp. 1130-1139. [10.3109/10715762.2012.692787]
Genetic polymorphisms of antioxidant enzymes as risk factors for oxidative stress-associated complications in preterm infants.
GIUSTI, BETTI;VESTRINI, ANNA;POGGI, CHIARA;MAGI, ALBERTO;ABBATE, ROSANNA;DANI, CARLO
2012
Abstract
We aimed to identify specific polymorphisms of genes encoding for superoxide dismutase (SOD) 1 (cytoplasmic Cu/ZnSOD), SOD2 (mitochondrial MnSOD), SOD3 (extracellular Cu/ZnSOD), and CAT in a cohort of preterm infants and correlate their presence to the development of RDS, BPD, IVH and ROP. We carried out a retrospective study to evaluate the allele frequency and the genotype distribution of polymorphisms of SODs and CAT in a population of preterm neonates (n=152) with a gestational age ≤28 weeks according to the presence or absence of RDS, BPD, IVH, and ROP. Moreover, we evaluated through the haplotype reconstruction analysis whether combinations of the selected polymorphisms are related to the occurrence of RDS, BPD, IVH and ROP. We found that rs8192287 SOD3 polymorphism is an independent protective factor for all grade IVH, while rs4880 and rs5746136 SOD2 polymorphisms are associated with a lower gestational age (rs4880, rs5746136) and birth weight (rs4880). Haplotypes reconstruction showed that SOD1 (GG) decreased the risk of RDS, IVH, and ROP; SOD2 (GT) increased the risk of BPD and decreased the risk of RDS, IVH, and ROP; SOD3 (TGC) decreased the risk of BPD and IVH; and 4) CAT (CTC) decreased the risk of RDS. Conclusions: the rs8192287 SOD3 polymorphism is per se an independent predictor of a decreased risk of developing IVH. Different SOD2 polymorphisms are associated per se with a lower gestational age and/or birth weight, and haplotypes of SOD1, SOD3, and CAT genes may be independent protecting or risk markers for prematurity complications.File | Dimensione | Formato | |
---|---|---|---|
FreeRadicalResearch2012.pdf
Accesso chiuso
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Tutti i diritti riservati
Dimensione
178.64 kB
Formato
Adobe PDF
|
178.64 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.