Pharmacol Res. 1998 Feb;37(2):83-5. Redundant down-regulation pathways for p53. Cinelli M, Magnelli L, Chiarugi V. Source Laboratory of Molecular Biology, University of Florence, Italy. Abstract The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and active p53 isoforms. The mechanisms prolonging p53 half life, following irradiation, are also discussed. PMID: 9572060 [PubMed - indexed for MEDLINE]
Redundant down-regulation pathways for p53 / M.CINELLI; L.MAGNELLI; V.CHIARUGI. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 37:(1998), pp. 83-85. [10.1006/phrs.1997.0269]
Redundant down-regulation pathways for p53.
CINELLI, MARINA;MAGNELLI, LUCIA;CHIARUGI, VINCENZO
1998
Abstract
Pharmacol Res. 1998 Feb;37(2):83-5. Redundant down-regulation pathways for p53. Cinelli M, Magnelli L, Chiarugi V. Source Laboratory of Molecular Biology, University of Florence, Italy. Abstract The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and active p53 isoforms. The mechanisms prolonging p53 half life, following irradiation, are also discussed. PMID: 9572060 [PubMed - indexed for MEDLINE]
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