Vaccines have made the second most major contribution to the control and eradication of infectious diseases after the distribution of clean water Modern vaccine concepts stem from early empirical approaches to variolation and vaccination The germ theory opened the door to a more relevant knowledge-based vaccine development process Since the late 18th century, several important techniques to produce effective vaccines have been developed: Attenuation and inactivation of pathogens at end of the 19th century Toxoids and bacterial cancer immunotherapy in the 1920s Use of adjuvants in the 1920s Embryonated eggs to grow viruses in the 1930s Cell cultures to grow viruses in the 1950s Vaccines based on split pathogens or subunits in the 1970s Recombinant DNA approach in the 1980s Conjugation of polysaccharides to protein carriers in the 1980s Reassortment of viral genes in the 1990s Dendritic cell vaccines for cancer treatment in 2010
Vaccine evolution / P. Bonanni; J. Ignacio Santos. - STAMPA. - (2011), pp. 1-24. [10.1016/j.pervac.2011.05.001]
Vaccine evolution
BONANNI, PAOLO;
2011
Abstract
Vaccines have made the second most major contribution to the control and eradication of infectious diseases after the distribution of clean water Modern vaccine concepts stem from early empirical approaches to variolation and vaccination The germ theory opened the door to a more relevant knowledge-based vaccine development process Since the late 18th century, several important techniques to produce effective vaccines have been developed: Attenuation and inactivation of pathogens at end of the 19th century Toxoids and bacterial cancer immunotherapy in the 1920s Use of adjuvants in the 1920s Embryonated eggs to grow viruses in the 1930s Cell cultures to grow viruses in the 1950s Vaccines based on split pathogens or subunits in the 1970s Recombinant DNA approach in the 1980s Conjugation of polysaccharides to protein carriers in the 1980s Reassortment of viral genes in the 1990s Dendritic cell vaccines for cancer treatment in 2010I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.