We describe the RPF web server, a quality assessment tool for protein NMR structures. The RPF server measures the 'goodness-of-fit' of the 3D structure with NMR chemical shift and unassigned NOESY data, and calculates a discrimination power (DP) score, which estimates the differences between the fits of the query structures and random coil structures to these experimental data. The DP-score is an accuracy predictor of the query structure. The RPF server also maps local structure quality measures onto the 3D structure using an online molecular viewer, and onto the NMR spectra, allowing refinement of the structure and/or NOESY peak list data. The RPF server is available at: http://nmr.cabm.rutgers.edu/rpf.

RPF: a quality assessment tool for protein NMR structures / Y. J. Huang;A. Rosato;G. Singh;G. T. Montelione. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - STAMPA. - 40:(2012), pp. W542-W546. [10.1093/nar/gks373]

RPF: a quality assessment tool for protein NMR structures

ROSATO, ANTONIO;
2012

Abstract

We describe the RPF web server, a quality assessment tool for protein NMR structures. The RPF server measures the 'goodness-of-fit' of the 3D structure with NMR chemical shift and unassigned NOESY data, and calculates a discrimination power (DP) score, which estimates the differences between the fits of the query structures and random coil structures to these experimental data. The DP-score is an accuracy predictor of the query structure. The RPF server also maps local structure quality measures onto the 3D structure using an online molecular viewer, and onto the NMR spectra, allowing refinement of the structure and/or NOESY peak list data. The RPF server is available at: http://nmr.cabm.rutgers.edu/rpf.
2012
40
W542
W546
Y. J. Huang;A. Rosato;G. Singh;G. T. Montelione
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/655418
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