Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of accuracy and precision with significant time and materials saving, as compared to the use of organic solvents in a three steps extraction procedure.
Microdetermination of some tricyclic psychotropic drugs and their N-demethylated metabolites by GLC with nitrogen-phosphorus sensitive detection / Sgaragli GP;L. Della Corte; M.G. Giovannini;Ninci R;Franco C;Nardini M. - In: BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE. - ISSN 0037-8771. - STAMPA. - 60:(1984), pp. 1757-1763.
Microdetermination of some tricyclic psychotropic drugs and their N-demethylated metabolites by GLC with nitrogen-phosphorus sensitive detection
DELLA CORTE, LAURA;GIOVANNINI, MARIA GRAZIA;
1984
Abstract
Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of accuracy and precision with significant time and materials saving, as compared to the use of organic solvents in a three steps extraction procedure.
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