This chapter discusses the principal aspects of the regulation of acetylcholine (ACh) release in the brain. The study of ACh release coupled with the recording of neuronal activity and the study of behavior is the most direct approach to understand the role of central cholinergic neurons; identifying metabolic conditions, neurotransmitters, and drugs that may modify their activity. The cholinergic neurons and their fibers are always mixed with noncholinergic neurons. The ACh release from many nerve endings is collected to quantify it, relatively large brain regions, also containing many noncholinergic nerve endings, are required, and irrespective of the procedure used for measuring ACh release. Thus, correlations between electrical activity of specific neuronal pathways and ACh release become approximate. Similarly approximate is the correlation between ACh release and the behavior. The chapter reviews the conditions influencing ACh release in the brain and is illustrated by examples taken from in vivo and in vitro studies. The methods that are used for studying ACh release in the brain are presented in the chapter.
Principal aspects of the regulation of acetylcholine release in the brain / G. PEPEU; F. CASAMENTI; M.G. GIOVANNINI; M.G. VANNUCCHI; F. PEDATA. - STAMPA. - (1991), pp. 273-278.
Principal aspects of the regulation of acetylcholine release in the brain
PEPEU, GIANCARLO;CASAMENTI, FIORELLA;M. G. GIOVANNINI;VANNUCCHI, MARIA;PEDATA, FELICITA
1991
Abstract
This chapter discusses the principal aspects of the regulation of acetylcholine (ACh) release in the brain. The study of ACh release coupled with the recording of neuronal activity and the study of behavior is the most direct approach to understand the role of central cholinergic neurons; identifying metabolic conditions, neurotransmitters, and drugs that may modify their activity. The cholinergic neurons and their fibers are always mixed with noncholinergic neurons. The ACh release from many nerve endings is collected to quantify it, relatively large brain regions, also containing many noncholinergic nerve endings, are required, and irrespective of the procedure used for measuring ACh release. Thus, correlations between electrical activity of specific neuronal pathways and ACh release become approximate. Similarly approximate is the correlation between ACh release and the behavior. The chapter reviews the conditions influencing ACh release in the brain and is illustrated by examples taken from in vivo and in vitro studies. The methods that are used for studying ACh release in the brain are presented in the chapter.File | Dimensione | Formato | |
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Vannucchi MG Progr Brain Res 1991.pdf
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