Differential scanning calorimetry supported by X-ray powder diffraction has been applied to the analysis of cogrinding-induced crystallinity changes of naproxen in mixtures with maltohexaose. Relevant factors were the mixture composition and the duration of mechanical treatment which did not affect the chemical integrity of the drug. Maltohexaose was particularly active as amorphizing agent in the mixture of equimolar composition.
DIFFERENTIAL SCANNING CALORIMETRY ANALYSIS OF CRYSTALLINITY CHANGES OF NAPROXEN IN GROUNDD MIXTURES WITH MALTOHEXAOSE, THE NON-CYCLIC ANALOG OF ALPHA-CYCLODEXTRIN / G.P. Bettinetti; M. Sorrenti; A. Negri; P. Mura; M.T. Faucci; M. Setti. - STAMPA. - (1998), pp. 367-370. (Intervento presentato al convegno 9TH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS tenutosi a SANTIAGO DE COMPOSTELA nel 31/05-03/06 1998).
DIFFERENTIAL SCANNING CALORIMETRY ANALYSIS OF CRYSTALLINITY CHANGES OF NAPROXEN IN GROUNDD MIXTURES WITH MALTOHEXAOSE, THE NON-CYCLIC ANALOG OF ALPHA-CYCLODEXTRIN
BETTINETTI, GIAMPIERO;MURA, PAOLA ANGELA;
1998
Abstract
Differential scanning calorimetry supported by X-ray powder diffraction has been applied to the analysis of cogrinding-induced crystallinity changes of naproxen in mixtures with maltohexaose. Relevant factors were the mixture composition and the duration of mechanical treatment which did not affect the chemical integrity of the drug. Maltohexaose was particularly active as amorphizing agent in the mixture of equimolar composition.
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