The combined effect of different acids (nitric, citric, lactic, malic) and cyclodextrins, both natural and derivative on the enhancement of the aqueous solubility of econazole was investigated. Multicomponent complex formation was always more effective than salt formation or binary complexation. The best reults were obtained for the combination of the drug with alpha-cyclodextrin and lactic acid in the respective molar ratios 1:1:2.5, which gave an increase of solubility of more than 4200 times with respect to the pure drug.
IMPROVEMENT OF ECONAZOLE SOLUBILITY IN MULTICOMPONENT SYSTEMS WITH CYCLODEXTRINS AND ACIDS / P. Mura; G. Franchi; M.T. Faucci; A. Manderioli; G. Bramanti. - STAMPA. - (1998), pp. 375-378. (Intervento presentato al convegno 9TH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS tenutosi a SANTIAGO DE COMPOSTELA nel 31/05/1998 - 3/06/1998).
IMPROVEMENT OF ECONAZOLE SOLUBILITY IN MULTICOMPONENT SYSTEMS WITH CYCLODEXTRINS AND ACIDS
MURA, PAOLA ANGELA;BRAMANTI, GIAMPIERO
1998
Abstract
The combined effect of different acids (nitric, citric, lactic, malic) and cyclodextrins, both natural and derivative on the enhancement of the aqueous solubility of econazole was investigated. Multicomponent complex formation was always more effective than salt formation or binary complexation. The best reults were obtained for the combination of the drug with alpha-cyclodextrin and lactic acid in the respective molar ratios 1:1:2.5, which gave an increase of solubility of more than 4200 times with respect to the pure drug.
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