Lifespan is attributable to genetic factors and some studies have attempted to identify putative genes implicated in human longevity. Several genetic loci have been associated with longevity, but some of these are not replicable, probably due to the vast differences among ethnicities. We analyzed in 128 Italian long-lived individuals and 150 unrelated healthy subjects, the recently reported association between rs189037 in the ataxia-telangiectasia mutated gene promoter and longevity in Chinese nonagenarians/centenarians. Our study confirms the association between the rs189037 C/T genotype and longevity in Italian centenarians, with an odds ratio of 1.85 (95 % CI 0.99-3.45). To understand the genetic basis for longevity is an extraordinarily difficult task, and therefore it is important to replicate any positive findings, especially if detected in other ethnic groups, in order to reach reliable conclusions on the real effect that candidate genes have on longevity.

Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians / Piaceri I; Bagnoli S; Tedde A; Sorbi S; Nacmias B.. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - STAMPA. - 34:(2013), pp. 573-575.

Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians

PIACERI, IRENE;BAGNOLI, SILVIA;TEDDE, ANDREA;SORBI, SANDRO;NACMIAS, BENEDETTA
2013

Abstract

Lifespan is attributable to genetic factors and some studies have attempted to identify putative genes implicated in human longevity. Several genetic loci have been associated with longevity, but some of these are not replicable, probably due to the vast differences among ethnicities. We analyzed in 128 Italian long-lived individuals and 150 unrelated healthy subjects, the recently reported association between rs189037 in the ataxia-telangiectasia mutated gene promoter and longevity in Chinese nonagenarians/centenarians. Our study confirms the association between the rs189037 C/T genotype and longevity in Italian centenarians, with an odds ratio of 1.85 (95 % CI 0.99-3.45). To understand the genetic basis for longevity is an extraordinarily difficult task, and therefore it is important to replicate any positive findings, especially if detected in other ethnic groups, in order to reach reliable conclusions on the real effect that candidate genes have on longevity.
2013
34
573
575
Piaceri I; Bagnoli S; Tedde A; Sorbi S; Nacmias B.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/709926
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