The invention relates to a process for the improvement of spermatozoa fertilization activity, in particular for the increase of spermatozoa motility by inhibiting the enzyme phosphatidylinositol-3 kinase (PI3K). The invention further relates to uses and methods of PI3K inhibitors in infertility and assisted reproduction techniques (ART) as well as to a medium for storage and/or transportation of spermatozoa comprising PI3K inhibitors. The PI3K inhibitors are selected from the group consisting of 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), wortmannin, quercetin, and derivatives and analogues thereof.
PROCESS FOR THE IMPROVEMENT OF SPERMATOZOA FERTILIZATION ACTIVITY / Luconi M; Baldi E; Forti G. - (2001).
PROCESS FOR THE IMPROVEMENT OF SPERMATOZOA FERTILIZATION ACTIVITY
LUCONI, MICHAELA;BALDI, ELISABETTA;FORTI, GIANNI
2001
Abstract
The invention relates to a process for the improvement of spermatozoa fertilization activity, in particular for the increase of spermatozoa motility by inhibiting the enzyme phosphatidylinositol-3 kinase (PI3K). The invention further relates to uses and methods of PI3K inhibitors in infertility and assisted reproduction techniques (ART) as well as to a medium for storage and/or transportation of spermatozoa comprising PI3K inhibitors. The PI3K inhibitors are selected from the group consisting of 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), wortmannin, quercetin, and derivatives and analogues thereof.
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