A new application of the dihydroazulene/vinylheptafulvene (DHA/VHF) system as a chemodosimeter for thiols is reported herein. A color change visible to the naked eye can be detected in acetonitrile/water (4:1) in the presence of cysteine and alkanethiols but not with other amino acids. The higher reactivity of DHA towards cysteine compared with VHF has been demonstrated. The easy synthesis of the main core and its versatility in terms of structural and physicochemical changes are essential elements for developing a new family of thiol-specific probes with higher selectivity and sensitivity than the reported prototype.
Colorimetric Probe for the Detection of Thiols: The Dihydroazulene/ Vinylheptafulvene System / Martina Cacciarini;* Eduardo A. Della Pia; Mogens B. Nielsen. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1099-0690. - STAMPA. - (2012), pp. 6064-6069. [10.1002/ejoc.201200887]
Colorimetric Probe for the Detection of Thiols: The Dihydroazulene/ Vinylheptafulvene System
CACCIARINI, MARTINA;
2012
Abstract
A new application of the dihydroazulene/vinylheptafulvene (DHA/VHF) system as a chemodosimeter for thiols is reported herein. A color change visible to the naked eye can be detected in acetonitrile/water (4:1) in the presence of cysteine and alkanethiols but not with other amino acids. The higher reactivity of DHA towards cysteine compared with VHF has been demonstrated. The easy synthesis of the main core and its versatility in terms of structural and physicochemical changes are essential elements for developing a new family of thiol-specific probes with higher selectivity and sensitivity than the reported prototype.
| File | Dimensione | Formato | |
|---|---|---|---|
|
EurJOC_2012.pdf
Accesso chiuso
Tipologia:
Versione finale referata (Postprint, Accepted manuscript)
Licenza:
Tutti i diritti riservati
Dimensione
545.24 kB
Formato
Adobe PDF
|
545.24 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
