A higher tissue water level seems to facilitate the penetration of the antibiotic into the tissue according to the pharmacokinetic characteristics of ceftizoxime: high amount of free drug (not bound to plasma proteins) and high hydrosolubility.
Intraoperative positive fluid balance improves tissue diffusion of ceftizoxime / Di Filippo A;Cammelli R;Novelli A;Mazzei T;Tonelli F;Fallani S;Cassetta MI;Messeri D;De Gaudio AR. - In: CHEMOTHERAPY. - ISSN 0009-3157. - STAMPA. - 51:(2005), pp. 51-56. [10.1159/000085610]
Intraoperative positive fluid balance improves tissue diffusion of ceftizoxime.
DI FILIPPO, ALESSANDRO;NOVELLI, ANDREA;MAZZEI, TERESITA;TONELLI, FRANCESCO;DE GAUDIO, ANGELO RAFFAELE
2005
Abstract
A higher tissue water level seems to facilitate the penetration of the antibiotic into the tissue according to the pharmacokinetic characteristics of ceftizoxime: high amount of free drug (not bound to plasma proteins) and high hydrosolubility.
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