Complexes of diazoxide (3-methyl-7-chloro-1,2,4-benzothiadiazine-1,1-dioxide) - an antihypertensive and hyperglycemic pharmacological agent - with a series of transition- and main-group di-, triand tetravalent metal ions were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes were tested as inhibitors of the enzyme carbonic anhydrase (CA), proving modest activity towards CA II and better inhibition of CA I.
Complexes with biologically active ligands. Part 1. Synthesis of coordination compounds of diazoxide with transition- and main-group cations / C. T. Supuran. - In: METAL-BASED DRUGS. - ISSN 0793-0291. - STAMPA. - 3:(1996), pp. 25-30. [10.1155/MBD.1996.25]
Complexes with biologically active ligands. Part 1. Synthesis of coordination compounds of diazoxide with transition- and main-group cations.
SUPURAN, CLAUDIU TRANDAFIR
1996
Abstract
Complexes of diazoxide (3-methyl-7-chloro-1,2,4-benzothiadiazine-1,1-dioxide) - an antihypertensive and hyperglycemic pharmacological agent - with a series of transition- and main-group di-, triand tetravalent metal ions were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes were tested as inhibitors of the enzyme carbonic anhydrase (CA), proving modest activity towards CA II and better inhibition of CA I.
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