A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.
Carbonic anhydrase activators. VII. Isozyme II activation by bisazolyl-methanes, -ethanes and related azoles / C. T. Supuran;A. T. Balaban;P. Cabildo;R. M. Claramunt;J. L. Lavandera;J. Elguero. - In: BIOLOGICAL & PHARMACEUTICAL BULLETIN. - ISSN 0918-6158. - STAMPA. - 16:(1993), pp. 1236-1239.
Carbonic anhydrase activators. VII. Isozyme II activation by bisazolyl-methanes, -ethanes and related azoles.
SUPURAN, CLAUDIU TRANDAFIR;
1993
Abstract
A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.
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