N-substituted benzenesulfonamides, incorporating the N-amino-, N-hydroxy- and N-methoxy-moieties at the sulfonamide zinc binding group, have been investigated as CAIs by means of inhibition and structural studies, unraveling interesting aspects related to their inhibition mechanism.
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II / A. D. Fiore;A. Maresca;V. Alterio;C. T. Supuran;G. D. Simone. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 47:(2011), pp. 11636-11638. [10.1039/c1cc14575d]
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II.
SUPURAN, CLAUDIU TRANDAFIR;
2011
Abstract
N-substituted benzenesulfonamides, incorporating the N-amino-, N-hydroxy- and N-methoxy-moieties at the sulfonamide zinc binding group, have been investigated as CAIs by means of inhibition and structural studies, unraveling interesting aspects related to their inhibition mechanism.
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