Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes in mammals, being involved in numerous biosynthetic processes, including gluconeogenesis, lipogenesis and ureagenesis. It has recently emerged that CA inhibitors (CAIs) targeting the mitochondrial isoforms CA VA and VB have potential as novel antiobesity drugs. This Editorial discusses the biochemical and biological rationale for the use of CAIs in the management of obesity.
Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity / C. T. Supuran. - In: EXPERT OPINION ON EMERGING DRUGS. - ISSN 1472-8214. - STAMPA. - 17:(2012), pp. 11-15. [10.1517/14728214.2012.664132]
Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity.
SUPURAN, CLAUDIU TRANDAFIR
2012
Abstract
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes in mammals, being involved in numerous biosynthetic processes, including gluconeogenesis, lipogenesis and ureagenesis. It has recently emerged that CA inhibitors (CAIs) targeting the mitochondrial isoforms CA VA and VB have potential as novel antiobesity drugs. This Editorial discusses the biochemical and biological rationale for the use of CAIs in the management of obesity.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.