Piperazine derivatives possessing nootropic activity

Piperazine derivatives with general structure (l) are described. There: <CHEM>R1 can be H or C1-5 alkyl; R2 and R3 are both H or linked together to from a bridge -CH2; X can be H, F, OCH3, Cl, NO2, NH2, CH3; Z can be CO, SO2. The compounds described above are endowed with an interesting nootropic activity that makes them suitable to treat neurodegenerative diseases such as Alzheimer's disease.