NAD is a vital molecule in all organisms. It is a key component of both energy and signal transduction - processes that undergo crucial changes in cancer cells. NAD(+)-dependent signalling pathways are many and varied, and they regulate fundamental events such as transcription, DNA repair, cell cycle progression, apoptosis and metabolism. Many of these processes have been linked to cancer development. Given that NAD(+)-dependent signalling reactions involve the degradation of the molecule, permanent nucleotide resynthesis through different biosynthetic pathways is crucial for incessant cancer cell proliferation. This necessity supports the targeting of NAD metabolism as a new therapeutic concept for cancer treatment.

The NAD metabolome - a key determinant of cancer cell biology / A. Chiarugi;C. Dölle;R. Felici;M. Ziegler. - In: NATURE REVIEWS CANCER. - ISSN 1474-175X. - STAMPA. - 12:(2012), pp. 741-752. [10.1038/nrc3340]

The NAD metabolome - a key determinant of cancer cell biology.

CHIARUGI, ALBERTO;FELICI, ROBERTA;
2012

Abstract

NAD is a vital molecule in all organisms. It is a key component of both energy and signal transduction - processes that undergo crucial changes in cancer cells. NAD(+)-dependent signalling pathways are many and varied, and they regulate fundamental events such as transcription, DNA repair, cell cycle progression, apoptosis and metabolism. Many of these processes have been linked to cancer development. Given that NAD(+)-dependent signalling reactions involve the degradation of the molecule, permanent nucleotide resynthesis through different biosynthetic pathways is crucial for incessant cancer cell proliferation. This necessity supports the targeting of NAD metabolism as a new therapeutic concept for cancer treatment.
2012
12
741
752
A. Chiarugi;C. Dölle;R. Felici;M. Ziegler
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/777155
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