Antiaggregant therapy with aspirin and clopidogrel has an important role in treatment of patients with acute coronary syndrome (ACS) to reduce the risk of major adverse cardiovascular events (MACE; myocardial infarction, cardiovascular death, stent thrombosis and stroke) [1]. Clopidogrel has a substantial benefit in high-risk patients undergoing percutaneous coronary intervention (PCI) and stent implantation. Despite adequate antiaggregant treatment, MACE occur in these patients. Patients who develop MACE have a high-on-clopidogrel platelet reactivity (HPR), suggesting that inadequate responsiveness to clopidogrel is one of the main causes of thrombotic events.

Current status of clopidogrel pharmacogenomics / Giusti B;Gori AM;Marcucci R;Abbate R. - In: PHARMACOGENOMICS. - ISSN 1462-2416. - STAMPA. - 13:(2012), pp. 1671-1674. [10.2217/pgs.12.153]

Current status of clopidogrel pharmacogenomics.

GIUSTI, BETTI;GORI, ANNA MARIA;MARCUCCI, ROSSELLA;ABBATE, ROSANNA
2012

Abstract

Antiaggregant therapy with aspirin and clopidogrel has an important role in treatment of patients with acute coronary syndrome (ACS) to reduce the risk of major adverse cardiovascular events (MACE; myocardial infarction, cardiovascular death, stent thrombosis and stroke) [1]. Clopidogrel has a substantial benefit in high-risk patients undergoing percutaneous coronary intervention (PCI) and stent implantation. Despite adequate antiaggregant treatment, MACE occur in these patients. Patients who develop MACE have a high-on-clopidogrel platelet reactivity (HPR), suggesting that inadequate responsiveness to clopidogrel is one of the main causes of thrombotic events.
2012
13
1671
1674
Giusti B;Gori AM;Marcucci R;Abbate R
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/785728
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