Clot lysis time (CLT), measuring plasma fibrinolytic potential, provides a global overview of fibrinolysis. Hypofibrinolysis has been found to be a potential risk factor for arterial and venous thrombosis. The mechanisms determining pulmonary embolism (PE) and its resolution are not completely understood. Recent data suggest that fibrin(ogen) characteristics may be relevant in determining the possible resistance to plasmin. It is reported that fibrin resistance to lysis occurs in patients with PE.
Fibrinolytic inhibitors and fibrin characteristics determine a hypofibrinolytic state in patients with pulmonary embolism / Cellai AP;Lami D;Antonucci E;Fiorillo C;Becatti M;Olimpieri B;Bani D;Grifoni E;Cenci C;Marcucci R;Mannini L;Poli D;Abbate R;Prisco D. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - STAMPA. - 109:(2013), pp. 565-567. [10.1160/TH12-09-0648]
Fibrinolytic inhibitors and fibrin characteristics determine a hypofibrinolytic state in patients with pulmonary embolism.
FIORILLO, CLAUDIA;BECATTI, MATTEO;OLIMPIERI, BENEDETTA;BANI, DANIELE;GRIFONI, ELISA;MARCUCCI, ROSSELLA;ABBATE, ROSANNA;PRISCO, DOMENICO
2013
Abstract
Clot lysis time (CLT), measuring plasma fibrinolytic potential, provides a global overview of fibrinolysis. Hypofibrinolysis has been found to be a potential risk factor for arterial and venous thrombosis. The mechanisms determining pulmonary embolism (PE) and its resolution are not completely understood. Recent data suggest that fibrin(ogen) characteristics may be relevant in determining the possible resistance to plasmin. It is reported that fibrin resistance to lysis occurs in patients with PE.
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