LP211 is an agonist of serotonin (5-hydroxytryptamine, 5-HT) receptor 7 (5-HT7). It is proposed for a role in neurogenesis and in patho-physiological processes like anxiety / depression, cognitive / sleep disturbances, and impaired coping with stress (1). Evidences demonstrate that it has consistent psychoactive effects onto exploratory motivation, anxiety-related profiles, and spontaneous circadian rhythm (2). Here, we investigated the long-term consequences of developmental exposure to LP211 on brain metabolism (by in vivo 1H MRS), anatomy (by DTI) and functionality (by functional connectivity, an emerging tool for studying brain functional organization widely applied to the study of the human brain, more recently to preclinical species).
Long term effects of developmental exposure to LP211, a new serotonin 7 receptor (5-HT7) agonist / Rossella Canese;Paola Porcari;Luisa Altabella;Francesca Zoratto;Francesco de Pasquale;Giovanni Laviola;Walter Adriani. - ELETTRONICO. - 20:(2012), pp. 3142-3142. (Intervento presentato al convegno 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) tenutosi a Melbourne, Australia nel 5-11 maggio 2012).
Long term effects of developmental exposure to LP211, a new serotonin 7 receptor (5-HT7) agonist
ZORATTO, FRANCESCA;
2012
Abstract
LP211 is an agonist of serotonin (5-hydroxytryptamine, 5-HT) receptor 7 (5-HT7). It is proposed for a role in neurogenesis and in patho-physiological processes like anxiety / depression, cognitive / sleep disturbances, and impaired coping with stress (1). Evidences demonstrate that it has consistent psychoactive effects onto exploratory motivation, anxiety-related profiles, and spontaneous circadian rhythm (2). Here, we investigated the long-term consequences of developmental exposure to LP211 on brain metabolism (by in vivo 1H MRS), anatomy (by DTI) and functionality (by functional connectivity, an emerging tool for studying brain functional organization widely applied to the study of the human brain, more recently to preclinical species).File | Dimensione | Formato | |
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