An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1′ specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).
Structure of matrix metalloproteinase-3 with a platinum-based inhibitor / Benny Danilo Belviso;Rocco Caliandro;Dritan Siliqi;Vito Calderone;Fabio Arnesano;Giovanni Natile. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 49:(2013), pp. 5492-5494. [10.1039/c3cc41278d]
Structure of matrix metalloproteinase-3 with a platinum-based inhibitor
CALDERONE, VITO;
2013
Abstract
An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1′ specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).
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