A case of autoimmune liver hepatitis is reported: the onset was triggered by consumption of green tea infusion in a patient taking oral contraceptives and irbesartan. We hypothesize that our patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives+irbesartan+green tea) that normally would not be able to cause damage. Her particular hepatic metabolism further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis.

Is green tea a potential trigger for autoimmune hepatitis? / E. Gallo;V. Maggini;M. Berardi;A. Pugi;R. Notaro;G. Talini;G. Vannozzi;S. Bagnoli;P. Forte;A. Mugelli;V. Annese;F. Firenzuoli;A. Vannacci. - In: PHYTOMEDICINE. - ISSN 0944-7113. - ELETTRONICO. - 20:(2013), pp. 1186-1189. [10.1016/j.phymed.2013.07.004]

Is green tea a potential trigger for autoimmune hepatitis?

GALLO, EUGENIA ROSARIA;MAGGINI, VALENTINA;BERARDI, MARGHERITA;PUGI, ALESSANDRA;MUGELLI, ALESSANDRO;FIRENZUOLI, FABIO;VANNACCI, ALFREDO
2013

Abstract

A case of autoimmune liver hepatitis is reported: the onset was triggered by consumption of green tea infusion in a patient taking oral contraceptives and irbesartan. We hypothesize that our patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives+irbesartan+green tea) that normally would not be able to cause damage. Her particular hepatic metabolism further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis.
2013
20
1186
1189
E. Gallo;V. Maggini;M. Berardi;A. Pugi;R. Notaro;G. Talini;G. Vannozzi;S. Bagnoli;P. Forte;A. Mugelli;V. Annese;F. Firenzuoli;A. Vannacci
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/818112
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