A hydrolytically stable mimetic of the tumour antigen GM 3 lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion,migration and resistance to apoptosis (anoikis).Notably,their ability to hamper melanoma-c ells adhesion and reduce the metastatic potential is enhanced when the two scaffolds,presenting adifferent shape,are used in combination.
Multivalent presentation of ahydrolytically stable GM 3 lactone mimetic as modulator of melanoma cells motility and adhesion / Barbara Richichi;Giuseppina Comito;Linda Cerofolini;Gabriele Gabrielli;Alberto Marra;Lisa Moni;Alice Pace;Lucia Pasquato;Paola Chiarugi;Alessandro Dondoni;Lucio Toma;Cristina Nativi. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 21:(2013), pp. 2756-2763. [10.1016/j.bmc.2013.03.021]
Multivalent presentation of ahydrolytically stable GM 3 lactone mimetic as modulator of melanoma cells motility and adhesion
RICHICHI, BARBARA;COMITO, GIUSEPPINA;CEROFOLINI, LINDA;GABRIELLI, GABRIELE;CHIARUGI, PAOLA;NATIVI, CRISTINA
2013
Abstract
A hydrolytically stable mimetic of the tumour antigen GM 3 lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion,migration and resistance to apoptosis (anoikis).Notably,their ability to hamper melanoma-c ells adhesion and reduce the metastatic potential is enhanced when the two scaffolds,presenting adifferent shape,are used in combination.
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