hIAPP amyloid deposition is a recognised hallmark of type two diabetes. Here we describe an unexpected hormetic effect of a short exposure to a low concentration of toxic hIAPP oligomers, with the upregulation of antioxidant enzymes via a RAGE-NADPH oxidase axis.
Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus / Elisabetta Borchi; Valentina Bargelli; Valentina Guidotti; Andrea Berti; Massimo Stefani; Chiara Nediani; Stefania Rigacci. - In: REDOX BIOLOGY. - ISSN 2213-2317. - STAMPA. - 2:(2014), pp. 114-122. [10.1016/j.redox.2013.12.005]
Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus
BORCHI, ELISABETTA;BARGELLI, VALENTINA;BERTI, ANDREA;STEFANI, MASSIMO;NEDIANI, CHIARA;RIGACCI, STEFANIA
2014
Abstract
hIAPP amyloid deposition is a recognised hallmark of type two diabetes. Here we describe an unexpected hormetic effect of a short exposure to a low concentration of toxic hIAPP oligomers, with the upregulation of antioxidant enzymes via a RAGE-NADPH oxidase axis.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Redox Biology 2014.pdf
accesso aperto
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Open Access
Dimensione
1.12 MB
Formato
Adobe PDF
|
1.12 MB | Adobe PDF |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
