The important proapoptotic activity of (–)-lentiginosine, the enantiomer of a natural glycosidase inhibitor, associated with its low cytotoxicity, suggests the study of the unknown receptor responsible for the triggering of the proapoptotic cascade. To this purpose two derivatives of (–)- lentiginosine which contain the biotin moiety as an affinity label and fluorescein as fluorophore, have been synthesized. Significantly, the compounds maintain a good activity as the hydroxylentiginosine precursor.
Synthesis of biotin and fluorescein labeled (–)-lentiginosine / Franca Maria Cordero; Carolina Vurchio; Beatrice Macchi; Antonella Minutolo; Alberto Brandi. - In: ARKIVOC. - ISSN 1551-7012. - ELETTRONICO. - 3:(2014), pp. 215-227. [10.3998/ark.5550190.p008.495]
Synthesis of biotin and fluorescein labeled (–)-lentiginosine
CORDERO, FRANCA MARIA;VURCHIO, CAROLINA;BRANDI, ALBERTO
2014
Abstract
The important proapoptotic activity of (–)-lentiginosine, the enantiomer of a natural glycosidase inhibitor, associated with its low cytotoxicity, suggests the study of the unknown receptor responsible for the triggering of the proapoptotic cascade. To this purpose two derivatives of (–)- lentiginosine which contain the biotin moiety as an affinity label and fluorescein as fluorophore, have been synthesized. Significantly, the compounds maintain a good activity as the hydroxylentiginosine precursor.File | Dimensione | Formato | |
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