The killer cell immunoglobulin-like receptor (KIR)–human leukocyte antigen (HLA) interaction represents an example of genetic epistasis, where the concomitant presence of specific genes or alleles encoding receptor–ligand units is necessary for the activity of natural killer (NK) cells. Our results not only improve the knowledge on KIR–HLA co-inheritance but also suggest that the different distributions of the KIR–HLA functional units may be generally driven by the climate in a north-to-south direction and by the pathogen variability connected to the different environmental conditions.
The distribution of KIR-HLA functional blocks is different from North to South of Italy / M.E. Fasano; S. Rendine; A. Pasi; A. Bontadini; E. Cosentini; C. Carcassi; C. Capittini; G. Cornacchini; A. Espadas de Arias; L. Garbarino; G. Carella; M.L. Mariotti; L. Mele; V. Miotti; A. Moscetti; S. Nesci; G. Ozzella; D. Piancatelli; B. Porfirio; M.R. Riva; G. Romeo; C. Tagliaferri; C. Lombardo; M. Testi; A. Amoroso; M. Martinetti. - In: TISSUE ANTIGENS. - ISSN 0001-2815. - STAMPA. - 83:(2014), pp. 168-173. [10.1111/tan.12299]
The distribution of KIR-HLA functional blocks is different from North to South of Italy
PORFIRIO, BERARDINO;
2014
Abstract
The killer cell immunoglobulin-like receptor (KIR)–human leukocyte antigen (HLA) interaction represents an example of genetic epistasis, where the concomitant presence of specific genes or alleles encoding receptor–ligand units is necessary for the activity of natural killer (NK) cells. Our results not only improve the knowledge on KIR–HLA co-inheritance but also suggest that the different distributions of the KIR–HLA functional units may be generally driven by the climate in a north-to-south direction and by the pathogen variability connected to the different environmental conditions.File | Dimensione | Formato | |
---|---|---|---|
tissue antigens KIR-HLA.pdf
Accesso chiuso
Tipologia:
Versione finale referata (Postprint, Accepted manuscript)
Licenza:
Tutti i diritti riservati
Dimensione
490.62 kB
Formato
Adobe PDF
|
490.62 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.