In historical times epidemics and pandemics killed large proportions of the European population, with likely consequences for the human genome as a result of positive selection acting on protective alleles. Pathophysiological evidence has suggested, for example, that cystic fibrosis mutations may confer resistance to cholera or other chloride-secreting diarrhoeas, whereas a high incidence of the CCR5-Delta32 mutation, which nowadays plays a substantial role in immunity against HIV-I infection, has been proposed to have provided some immunity against plague (...............)

"Evolutionary consequences of the past pandemics" / Barbara Bramanti; Stephanie Hänsch; Magdalena Bogus; Anja Meister; Claudio Ottoni; Antonella Lannino; Joachim Burger; Mark G. Thomas. - ELETTRONICO. - (2013), pp. 1-2. (Intervento presentato al convegno Ancient DNA: applications in human evolutionary history tenutosi a London nel 20-21 Novembre 2013).

"Evolutionary consequences of the past pandemics"

BRAMANTI, BARBARA;LANNINO, ANTONELLA;
2013

Abstract

In historical times epidemics and pandemics killed large proportions of the European population, with likely consequences for the human genome as a result of positive selection acting on protective alleles. Pathophysiological evidence has suggested, for example, that cystic fibrosis mutations may confer resistance to cholera or other chloride-secreting diarrhoeas, whereas a high incidence of the CCR5-Delta32 mutation, which nowadays plays a substantial role in immunity against HIV-I infection, has been proposed to have provided some immunity against plague (...............)
2013
Abstract of the Royal Society Congress, 18-21 November 2013, London
Ancient DNA: applications in human evolutionary history
London
Barbara Bramanti; Stephanie Hänsch; Magdalena Bogus; Anja Meister; Claudio Ottoni; Antonella Lannino; Joachim Burger; Mark G. Thomas
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/849554
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