ObjectiveThe aim of this study was to evaluate the utility of screening for infections in case of isolated mild ventriculomegaly (imVM). MethodsWe retrospectively reviewed 141 cases of imVM. Screening for infections including TORCH, parvovirus B19, and syphilis was carried out in all cases. Follow-up ultrasound, fetal karyotype, and magnetic resonance imaging (MRI) were offered. Postnatal follow-up was obtained from pediatricians, medical records, parents, and postmortem reports in cases of termination of pregnancy or stillbirth. ResultsThe imVM was bilateral in 70 fetuses and unilateral in 71 and regressed during pregnancy in 66.6% of cases. Associated anomalies were observed in 15 cases with follow-up ultrasound and in seven cases with MRI. Fetal karyotype was abnormal in one fetus (47, XXY). Maternal IgM for parvovirus B19 resulted positive in 4.6% of cases, and one neonate was infected without any fetal/neonatal adverse consequence. Recent cytomegalovirus infection was documented in 4.4% of cases. Only in one case the infection was transmitted to the fetus; after 3years, the child has good neuromotor development but has severe hearing impairment. ConclusionsWhen this diagnosis occurs, tests could be limited to cytomegalovirus and parvovirus B19, whereas a complete TORCH screening is probably not necessary.

The utility of infection screening in isolated mild ventriculomegaly: an observational retrospective study on 141 fetuses / Lucia Pasquini; Giulia Masini; Claudia Gaini; Chiara Franchi; Michele Trotta; Carlo Dani; Mariarosaria Di Tommaso. - In: PRENATAL DIAGNOSIS. - ISSN 0197-3851. - ELETTRONICO. - 34:(2014), pp. 1295-1300. [10.1002/pd.4470]

The utility of infection screening in isolated mild ventriculomegaly: an observational retrospective study on 141 fetuses

DANI, CARLO;DI TOMMASO, MARIAROSARIA
2014

Abstract

ObjectiveThe aim of this study was to evaluate the utility of screening for infections in case of isolated mild ventriculomegaly (imVM). MethodsWe retrospectively reviewed 141 cases of imVM. Screening for infections including TORCH, parvovirus B19, and syphilis was carried out in all cases. Follow-up ultrasound, fetal karyotype, and magnetic resonance imaging (MRI) were offered. Postnatal follow-up was obtained from pediatricians, medical records, parents, and postmortem reports in cases of termination of pregnancy or stillbirth. ResultsThe imVM was bilateral in 70 fetuses and unilateral in 71 and regressed during pregnancy in 66.6% of cases. Associated anomalies were observed in 15 cases with follow-up ultrasound and in seven cases with MRI. Fetal karyotype was abnormal in one fetus (47, XXY). Maternal IgM for parvovirus B19 resulted positive in 4.6% of cases, and one neonate was infected without any fetal/neonatal adverse consequence. Recent cytomegalovirus infection was documented in 4.4% of cases. Only in one case the infection was transmitted to the fetus; after 3years, the child has good neuromotor development but has severe hearing impairment. ConclusionsWhen this diagnosis occurs, tests could be limited to cytomegalovirus and parvovirus B19, whereas a complete TORCH screening is probably not necessary.
2014
34
1295
1300
Lucia Pasquini; Giulia Masini; Claudia Gaini; Chiara Franchi; Michele Trotta; Carlo Dani; Mariarosaria Di Tommaso
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/888400
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