A d-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting the invasion inhibitory activity and capacity of blocking capillary network formation in vivo. © 2015 The Royal Society of Chemistry.

A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9 / Bianchini, Francesca; Calugi, Chiara; Ruzzolini, Jessica; Menchi, Gloria; Calorini, Lido; Guarna, Antonio; Trabocchi, Andrea. - In: MEDCHEMCOMM. - ISSN 2040-2503. - STAMPA. - 6:(2015), pp. 277-282. [10.1039/c4md00287c]

A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9

BIANCHINI, FRANCESCA;CALUGI, CHIARA;Ruzzolini, Jessica;MENCHI, GLORIA;CALORINI, LIDO;GUARNA, ANTONIO;TRABOCCHI, ANDREA
2015

Abstract

A d-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting the invasion inhibitory activity and capacity of blocking capillary network formation in vivo. © 2015 The Royal Society of Chemistry.
2015
6
277
282
Bianchini, Francesca; Calugi, Chiara; Ruzzolini, Jessica; Menchi, Gloria; Calorini, Lido; Guarna, Antonio; Trabocchi, Andrea
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1016958
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