The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed.
The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme / Luigi Messori;Tiziano Marzo;Antonello Merlino. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - ELETTRONICO. - 50:(2014), pp. 8360-8362. [10.1039/c4cc02254h]
The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme
MESSORI, LUIGI;MARZO, TIZIANO;
2014
Abstract
The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed.
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