Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy, which gains access to the circulation very early during disease progression. Within this scenario, detection of circulating tumor cells (CTCs), released into the peripheral blood before any detectable metastasis is established, may represent a promising diagnostic tool in ACC patients. Our group recently evaluated CTC presence in blood samples from 14 patients with ACC and 10 patients with adrenocortical adenoma (ACA) using a cytomorphologic technique based on filtration (ScreenCell). Filters were assessed immunocytochemically for adrenocortical markers such as MART-1, synaptophysin and steroidogenic factor 1 (SF-1). CTCs were detected in all ACC but not in ACA patients and immunostaining confirmed their adrenocortical nature. In ACC patients, the number of CTCs after surgery either remained stable or significantly decreased, confirming that mass removal may reduce the number of CTCs entering the bloodstream. Moreover, the number of postsurgical CTCs correlated with stage and tumor diameter, suggesting that this so-called liquid biopsy might be a useful mini-invasive tool for prognosis and for monitoring progression and response to treatments. In the near future, evaluation of the molecular expression profile of CTCs may help to develop tailored anti-metastatic therapies in ACC.

Endocrine Pathology: SY08-1 DETECTION OF CIRCULATING TUMOR CELLS IN ADRENOCORTICAL NEOPLASMS / C. Scatena;P. Pinzani;F. Salvianti;M. Paglierani;M. Luconi;M. Mannelli;G. Nesi. - In: CLINICAL MEDICINE INSIGHTS. PATHOLOGY. - ISSN 1179-5557. - STAMPA. - 46 Suppl 2:(2014), pp. S13-S14. [10.1097/01.PAT.0000454094.30256.58]

Endocrine Pathology: SY08-1 DETECTION OF CIRCULATING TUMOR CELLS IN ADRENOCORTICAL NEOPLASMS.

PINZANI, PAMELA;LUCONI, MICHAELA;MANNELLI, MASSIMO;NESI, GABRIELLA
2014

Abstract

Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy, which gains access to the circulation very early during disease progression. Within this scenario, detection of circulating tumor cells (CTCs), released into the peripheral blood before any detectable metastasis is established, may represent a promising diagnostic tool in ACC patients. Our group recently evaluated CTC presence in blood samples from 14 patients with ACC and 10 patients with adrenocortical adenoma (ACA) using a cytomorphologic technique based on filtration (ScreenCell). Filters were assessed immunocytochemically for adrenocortical markers such as MART-1, synaptophysin and steroidogenic factor 1 (SF-1). CTCs were detected in all ACC but not in ACA patients and immunostaining confirmed their adrenocortical nature. In ACC patients, the number of CTCs after surgery either remained stable or significantly decreased, confirming that mass removal may reduce the number of CTCs entering the bloodstream. Moreover, the number of postsurgical CTCs correlated with stage and tumor diameter, suggesting that this so-called liquid biopsy might be a useful mini-invasive tool for prognosis and for monitoring progression and response to treatments. In the near future, evaluation of the molecular expression profile of CTCs may help to develop tailored anti-metastatic therapies in ACC.
2014
46 Suppl 2
S13
S14
C. Scatena;P. Pinzani;F. Salvianti;M. Paglierani;M. Luconi;M. Mannelli;G. Nesi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/921333
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