Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16), p = 2.7 × 10(-3)) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95%CI: 1.03-1.21, p = 4.8 × 10(-3)). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied.
DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers / Osorio A; Milne RL; Kuchenbaecker K; Vaclová T; Pita G; Alonso R; Peterlongo P; Blanco I; de la Hoya M; Duran M; Díez O; Ramón Y Cajal T; Konstantopoulou I; Martínez-Bouzas C; Andrés Conejero R; Soucy P; McGuffog L; Barrowdale D; Lee A; Swe-Brca; Arver B; Rantala J; Loman N; Ehrencrona H; Olopade OI; Beattie MS; Domchek SM; Nathanson K; Rebbeck TR; Arun BK; Karlan BY; Walsh C; Lester J; John EM; Whittemore AS; Daly MB; Southey M; Hopper J; Terry MB; Buys SS; Janavicius R; Dorfling CM; van Rensburg EJ; Steele L; Neuhausen SL; Ding YC; Hansen TV; Jønson L; Ejlertsen B; Gerdes AM; Infante M; Herráez B; Moreno LT; Weitzel JN; Herzog J; Weeman K; Manoukian S; Peissel B; Zaffaroni D; Scuvera G; Bonanni B; Mariette F; Volorio S; Viel A; Varesco L; Papi L; Ottini L; Tibiletti MG; Radice P; Yannoukakos D; Garber J; Ellis S; Frost D; Platte R; Fineberg E; Evans G; Lalloo F; Izatt L; Eeles R; Adlard J; Davidson R; Cole T; Eccles D; Cook J; Hodgson S; Brewer C; Tischkowitz M; Douglas F; Porteous M; Side L; Walker L; Morrison P; Donaldson A; Kennedy J; Foo C; Godwin AK; Schmutzler RK; Wappenschmidt B; Rhiem K; Engel C; Meindl A; Ditsch N; Arnold N; Plendl HJ; Niederacher D; Sutter C; Wang-Gohrke S; Steinemann D; Preisler-Adams S; Kast K; Varon-Mateeva R; Gehrig A; Stoppa-Lyonnet D; Sinilnikova OM; Mazoyer S; Damiola F; Poppe B; Claes K; Piedmonte M; Tucker K; Backes F; Rodríguez G; Brewster W; Wakeley K; Rutherford T; Caldés T; Nevanlinna H; Aittomäki K; Rookus MA; van Os TA; van der Kolk L; de Lange JL; Meijers-Heijboer HE; van der Hout AH; van Asperen CJ; Gómez Garcia EB; Hoogerbrugge N; Collée JM; van Deurzen CH; van der Luijt RB; Devilee P; Hebon; Olah E; Lázaro C; Teulé A; Menéndez M; Jakubowska A; Cybulski C; Gronwald J; Lubinski J; Durda K; Jaworska-Bieniek K; Johannsson OT; Maugard C; Montagna M; Tognazzo S; Teixeira MR; Healey S; Investigators K; Olswold C; Guidugli L; Lindor N; Slager S; Szabo CI; Vijai J; Robson M; Kauff N; Zhang L; Rau-Murthy R; Fink-Retter A; Singer CF; Rappaport C; Geschwantler Kaulich D; Pfeiler G; Tea MK; Berger A; Phelan CM; Greene MH; Mai PL; Lejbkowicz F; Andrulis I; Mulligan AM; Glendon G; Toland AE; Bojesen A; Pedersen IS; Sunde L; Thomassen M; Kruse TA; Jensen UB; Friedman E; Laitman Y; Shimon SP; Simard J; Easton DF; Offit K; Couch FJ; Chenevix-Trench G; Antoniou AC; Benitez J.. - In: PLOS GENETICS. - ISSN 1553-7404. - ELETTRONICO. - (2014), pp. e1004256-e1004256.
DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers
PAPI, LAURA;
2014
Abstract
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16), p = 2.7 × 10(-3)) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95%CI: 1.03-1.21, p = 4.8 × 10(-3)). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied.
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