CASCELLA, ROBERTA
CASCELLA, ROBERTA
Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells
2011 Zampagni M; Cascella R; Casamenti F; Grossi C; Evangelisti E; Wright D; Becatti M; Liguri G; Mannini B; Campioni S; Chiti F; Cecchi C.
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
2017 Perni, Michele; Galvagnion, Céline; Maltsev, Alexander; Meisl, Georg; Müller, Martin B. D.; Challa, Pavan K.; Kirkegaard, Julius B.; Flagmeier, Patrick; Cohen, Samuel I. A.; Cascella, Roberta; Chen, Serene W.; Limboker, Ryan; Sormanni, Pietro; Heller, Gabriella T.; Aprile, Francesco A.; Cremades, Nunilo; Cecchi, Cristina; Chiti, Fabrizio; Nollen, Ellen A. A.; Knowles, Tuomas P. J.; Vendruscolo, Michele; Bax, Adriaan; Zasloff, Michael; M. Dobson, Christopher
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43
2022 Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti
Allele specific Taqman–based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients.
2010 Pinzani P; Salvianti F; Cascella R; Massi D; De Giorgi V; Pazzagli M; Orlando C.
Amyloid cytotoxicity depends on membrane lipid composition in Alzheimer's disease
2014 Nacmias B.; Evangelisti E.; Cascella R.; Bagnoli S.; Sorbi S.; Cecchi C.
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases
2022 Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi
Aβ oligomers dysregulate calcium homeostasis by mechanosensitive activation of AMPA and NMDA receptors.
2021 Giulia Fani, Benedetta Mannini, Giulia Vecchi, Roberta Cascella, Cristina Cecchi, Christopher M. Dobson, Michele Vendruscolo, Fabrizio Chiti
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
2016 Evangelisti, Elisa; Cascella, Roberta; Becatti, Matteo; Marrazza, Giovanna; Dobson, Christopher M.; Chiti, Fabrizio; Stefani, Massimo; Cecchi, Cristina
Calcium dyshomeostasis in Alzheimer’s disease pathogenesis
2021 Cascella R.; Cecchi C.
Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action
2011 B. Mannini; S. Campioni; M. Boninsegna; E. Palagano; R. Cascella; M. Zampagni; A. Penco; M. Wilson; S. Meehan; C. Roodveldt; A. Relini; C. Cecchi; F. Chiti
Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action
2012 B. Mannini; S. Campioni; M. Boninsegna; A. Penco; R. Cascella; M. Zampagni; M. Wilson; S. Meehan; C. Roodveldt; C. Dobson; A. Relini; C. Cecchi; F. Chiti
Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia
2016 Pasqualina Liana Scognamiglio; Concetta Di Natale; Marilisa Leone; Roberta Cascella; Cristina Cecchi; Lisa Lirussi; Giulia Antoniali; Domenico Riccardi; Giancarlo Morelli; Gianluca Tell; Fabrizio Chiti; Daniela Marasco
Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations
2016 Cappelli, S; Penco, A; Mannini, Benedetta; Cascella, Roberta; Wilson, M; Ecroyd, H; Li, X; Buxbaum, J; Dobson, Cm; Cecchi, Cristina; Relini, A; Chiti, Fabrizio
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
2022 Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi
Exploring the release of toxic oligomers from α-synuclein fibrils with antibodies and sted microscopy
2021 Bigi A.; Ermini E.; Chen S.W.; Cascella R.; Cecchi C.
Extracellular chaperones prevent Aβ42-induced toxicity in rat brains
2013 Roberta Cascella; Simona Conti; Francesca Tatini; Elisa Evangelisti; Tania Scartabelli; Fiorella Casamenti; Mark R. Wilson; Fabrizio Chiti; Cristina Cecchi.
Glutathione intake promotes longevity through the activation of SIR-2.1 and DAF-16 (FoxO) pathway in C. elegans
2014 Cascella, Roberta; Evangelisti, Elisa; Becatti, Matteo; Fiorillo, Claudia; Cecchi, Cristina
Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy
2016 Oropesa-Nuñez, R; Seghezza, S; Dante, S; Diaspro, A; Cascella, R; Cecchi, C; Stefani, M; Chiti, F; Canale, C
Light-responsive nanocomposite sponges for on demand chemical release with high spatial and dosage control
2013 Paolo Matteini; Maria Raffaella Martina; Giuliano Giambastiani; Francesca Tatini; Roberta Cascella; Fulvio Ratto; Cristina Cecchi; Gabriella Caminati; Luigi Dei; Roberto Pini
Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane
2010 Zampagni M; Evangelisti E; Cascella R; Liguri G; Becatti M; Pensalfini A; Uberti D; Cenini G; Memo M; Bagnoli S; Nacmias B; Sorbi S; Cecchi C.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells | 2011 | Zampagni M; Cascella R; Casamenti F; Grossi C; Evangelisti E; Wright D; Becatti M; Liguri G; Mannini B; Campioni S; Chiti F; Cecchi C. | |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity | 2017 | Perni, Michele; Galvagnion, Céline; Maltsev, Alexander; Meisl, Georg; Müller, Martin B. D.; Challa, Pavan K.; Kirkegaard, Julius B.; Flagmeier, Patrick; Cohen, Samuel I. A.; Cascella, Roberta; Chen, Serene W.; Limboker, Ryan; Sormanni, Pietro; Heller, Gabriella T.; Aprile, Francesco A.; Cremades, Nunilo; Cecchi, Cristina; Chiti, Fabrizio; Nollen, Ellen A. A.; Knowles, Tuomas P. J.; Vendruscolo, Michele; Bax, Adriaan; Zasloff, Michael; M. Dobson, Christopher | |
| A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43 | 2022 | Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti | |
| Allele specific Taqman–based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients. | 2010 | Pinzani P; Salvianti F; Cascella R; Massi D; De Giorgi V; Pazzagli M; Orlando C. | |
| Amyloid cytotoxicity depends on membrane lipid composition in Alzheimer's disease | 2014 | Nacmias B.; Evangelisti E.; Cascella R.; Bagnoli S.; Sorbi S.; Cecchi C. | |
| Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases | 2022 | Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi | |
| Aβ oligomers dysregulate calcium homeostasis by mechanosensitive activation of AMPA and NMDA receptors. | 2021 | Giulia Fani, Benedetta Mannini, Giulia Vecchi, Roberta Cascella, Cristina Cecchi, Christopher M. Dobson, Michele Vendruscolo, Fabrizio Chiti | |
| Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases | 2016 | Evangelisti, Elisa; Cascella, Roberta; Becatti, Matteo; Marrazza, Giovanna; Dobson, Christopher M.; Chiti, Fabrizio; Stefani, Massimo; Cecchi, Cristina | |
| Calcium dyshomeostasis in Alzheimer’s disease pathogenesis | 2021 | Cascella R.; Cecchi C. | |
| Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action | 2011 | B. Mannini; S. Campioni; M. Boninsegna; E. Palagano; R. Cascella; M. Zampagni; A. Penco; M. Wilson; S. Meehan; C. Roodveldt; A. Relini; C. Cecchi; F. Chiti | |
| Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action | 2012 | B. Mannini; S. Campioni; M. Boninsegna; A. Penco; R. Cascella; M. Zampagni; M. Wilson; S. Meehan; C. Roodveldt; C. Dobson; A. Relini; C. Cecchi; F. Chiti | |
| Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia | 2016 | Pasqualina Liana Scognamiglio; Concetta Di Natale; Marilisa Leone; Roberta Cascella; Cristina Cecchi; Lisa Lirussi; Giulia Antoniali; Domenico Riccardi; Giancarlo Morelli; Gianluca Tell; Fabrizio Chiti; Daniela Marasco | |
| Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations | 2016 | Cappelli, S; Penco, A; Mannini, Benedetta; Cascella, Roberta; Wilson, M; Ecroyd, H; Li, X; Buxbaum, J; Dobson, Cm; Cecchi, Cristina; Relini, A; Chiti, Fabrizio | |
| Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies | 2022 | Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi | |
| Exploring the release of toxic oligomers from α-synuclein fibrils with antibodies and sted microscopy | 2021 | Bigi A.; Ermini E.; Chen S.W.; Cascella R.; Cecchi C. | |
| Extracellular chaperones prevent Aβ42-induced toxicity in rat brains | 2013 | Roberta Cascella; Simona Conti; Francesca Tatini; Elisa Evangelisti; Tania Scartabelli; Fiorella Casamenti; Mark R. Wilson; Fabrizio Chiti; Cristina Cecchi. | |
| Glutathione intake promotes longevity through the activation of SIR-2.1 and DAF-16 (FoxO) pathway in C. elegans | 2014 | Cascella, Roberta; Evangelisti, Elisa; Becatti, Matteo; Fiorillo, Claudia; Cecchi, Cristina | |
| Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy | 2016 | Oropesa-Nuñez, R; Seghezza, S; Dante, S; Diaspro, A; Cascella, R; Cecchi, C; Stefani, M; Chiti, F; Canale, C | |
| Light-responsive nanocomposite sponges for on demand chemical release with high spatial and dosage control | 2013 | Paolo Matteini; Maria Raffaella Martina; Giuliano Giambastiani; Francesca Tatini; Roberta Cascella; Fulvio Ratto; Cristina Cecchi; Gabriella Caminati; Luigi Dei; Roberto Pini | |
| Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane | 2010 | Zampagni M; Evangelisti E; Cascella R; Liguri G; Becatti M; Pensalfini A; Uberti D; Cenini G; Memo M; Bagnoli S; Nacmias B; Sorbi S; Cecchi C. |