CASCELLA, ROBERTA
CASCELLA, ROBERTA
Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells
2011 Zampagni M; Cascella R; Casamenti F; Grossi C; Evangelisti E; Wright D; Becatti M; Liguri G; Mannini B; Campioni S; Chiti F; Cecchi C.
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
2017 Perni, Michele; Galvagnion, Céline; Maltsev, Alexander; Meisl, Georg; Müller, Martin B. D.; Challa, Pavan K.; Kirkegaard, Julius B.; Flagmeier, Patrick; Cohen, Samuel I. A.; Cascella, Roberta; Chen, Serene W.; Limboker, Ryan; Sormanni, Pietro; Heller, Gabriella T.; Aprile, Francesco A.; Cremades, Nunilo; Cecchi, Cristina; Chiti, Fabrizio; Nollen, Ellen A. A.; Knowles, Tuomas P. J.; Vendruscolo, Michele; Bax, Adriaan; Zasloff, Michael; M. Dobson, Christopher
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43
2022 Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF
2024 Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella
Allele specific Taqman–based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients.
2010 Pinzani P; Salvianti F; Cascella R; Massi D; De Giorgi V; Pazzagli M; Orlando C.
Amyloid cytotoxicity depends on membrane lipid composition in Alzheimer's disease
2014 Nacmias B.; Evangelisti E.; Cascella R.; Bagnoli S.; Sorbi S.; Cecchi C.
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases
2022 Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature
2023 Cascella R, Banchelli M, Abolghasem Ghadami S, Ami D, Gagliani MC, Bigi A, Staderini T, Tampellini D, Cortese K, Cecchi C, Natalello A, Adibi H, Matteini P, Chiti F.
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature
2023 Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility
2023 Claudia Capitini, Alessandra Bigi, Niccolò Parenti, Marco Emanuele, Niccolò Bianchi, Roberta Cascella, Cristina Cecchi, Laura Maggi, Francesco Annunziato, Francesco Saverio Pavone, Martino Calamai
Aβ oligomers dysregulate calcium homeostasis by mechanosensitive activation of AMPA and NMDA receptors.
2021 Giulia Fani, Benedetta Mannini, Giulia Vecchi, Roberta Cascella, Cristina Cecchi, Christopher M. Dobson, Michele Vendruscolo, Fabrizio Chiti
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
2016 Evangelisti, Elisa; Cascella, Roberta; Becatti, Matteo; Marrazza, Giovanna; Dobson, Christopher M.; Chiti, Fabrizio; Stefani, Massimo; Cecchi, Cristina
Calcium dyshomeostasis in Alzheimer’s disease pathogenesis
2021 Cascella R.; Cecchi C.
Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action
2011 B. Mannini; S. Campioni; M. Boninsegna; E. Palagano; R. Cascella; M. Zampagni; A. Penco; M. Wilson; S. Meehan; C. Roodveldt; A. Relini; C. Cecchi; F. Chiti
Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action
2012 B. Mannini; S. Campioni; M. Boninsegna; A. Penco; R. Cascella; M. Zampagni; M. Wilson; S. Meehan; C. Roodveldt; C. Dobson; A. Relini; C. Cecchi; F. Chiti
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
2023 Limbocker, Ryan; Cremades, Nunilo; Cascella, Roberta; Tessier, Peter M; Vendruscolo, Michele; Chiti, Fabrizio
Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia
2016 Pasqualina Liana Scognamiglio; Concetta Di Natale; Marilisa Leone; Roberta Cascella; Cristina Cecchi; Lisa Lirussi; Giulia Antoniali; Domenico Riccardi; Giancarlo Morelli; Gianluca Tell; Fabrizio Chiti; Daniela Marasco
Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations
2016 Cappelli, S; Penco, A; Mannini, Benedetta; Cascella, Roberta; Wilson, M; Ecroyd, H; Li, X; Buxbaum, J; Dobson, Cm; Cecchi, Cristina; Relini, A; Chiti, Fabrizio
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
2022 Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi
Exploring the Aβ1-42 fibrillogenesis timeline by atomic force microscopy and surface enhanced Raman spectroscopy
2024 Panagis Polykretis, Cristiano D'Andrea, Martina Banchelli, Liliana Napolitano, Roberta Cascella, Marella de Angelis, Paolo Matteini
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells | 2011 | Zampagni M; Cascella R; Casamenti F; Grossi C; Evangelisti E; Wright D; Becatti M; Liguri G; Mannini B; Campioni S; Chiti F; Cecchi C. | |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity | 2017 | Perni, Michele; Galvagnion, Céline; Maltsev, Alexander; Meisl, Georg; Müller, Martin B. D.; Challa, Pavan K.; Kirkegaard, Julius B.; Flagmeier, Patrick; Cohen, Samuel I. A.; Cascella, Roberta; Chen, Serene W.; Limboker, Ryan; Sormanni, Pietro; Heller, Gabriella T.; Aprile, Francesco A.; Cremades, Nunilo; Cecchi, Cristina; Chiti, Fabrizio; Nollen, Ellen A. A.; Knowles, Tuomas P. J.; Vendruscolo, Michele; Bax, Adriaan; Zasloff, Michael; M. Dobson, Christopher | |
| A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43 | 2022 | Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti | |
| A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF | 2024 | Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella | |
| Allele specific Taqman–based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients. | 2010 | Pinzani P; Salvianti F; Cascella R; Massi D; De Giorgi V; Pazzagli M; Orlando C. | |
| Amyloid cytotoxicity depends on membrane lipid composition in Alzheimer's disease | 2014 | Nacmias B.; Evangelisti E.; Cascella R.; Bagnoli S.; Sorbi S.; Cecchi C. | |
| Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases | 2022 | Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi | |
| An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature | 2023 | Cascella R, Banchelli M, Abolghasem Ghadami S, Ami D, Gagliani MC, Bigi A, Staderini T, Tampellini D, Cortese K, Cecchi C, Natalello A, Adibi H, Matteini P, Chiti F. | |
| An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature | 2023 | Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti | |
| APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility | 2023 | Claudia Capitini, Alessandra Bigi, Niccolò Parenti, Marco Emanuele, Niccolò Bianchi, Roberta Cascella, Cristina Cecchi, Laura Maggi, Francesco Annunziato, Francesco Saverio Pavone, Martino Calamai | |
| Aβ oligomers dysregulate calcium homeostasis by mechanosensitive activation of AMPA and NMDA receptors. | 2021 | Giulia Fani, Benedetta Mannini, Giulia Vecchi, Roberta Cascella, Cristina Cecchi, Christopher M. Dobson, Michele Vendruscolo, Fabrizio Chiti | |
| Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases | 2016 | Evangelisti, Elisa; Cascella, Roberta; Becatti, Matteo; Marrazza, Giovanna; Dobson, Christopher M.; Chiti, Fabrizio; Stefani, Massimo; Cecchi, Cristina | |
| Calcium dyshomeostasis in Alzheimer’s disease pathogenesis | 2021 | Cascella R.; Cecchi C. | |
| Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action | 2011 | B. Mannini; S. Campioni; M. Boninsegna; E. Palagano; R. Cascella; M. Zampagni; A. Penco; M. Wilson; S. Meehan; C. Roodveldt; A. Relini; C. Cecchi; F. Chiti | |
| Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action | 2012 | B. Mannini; S. Campioni; M. Boninsegna; A. Penco; R. Cascella; M. Zampagni; M. Wilson; S. Meehan; C. Roodveldt; C. Dobson; A. Relini; C. Cecchi; F. Chiti | |
| Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases | 2023 | Limbocker, Ryan; Cremades, Nunilo; Cascella, Roberta; Tessier, Peter M; Vendruscolo, Michele; Chiti, Fabrizio | |
| Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia | 2016 | Pasqualina Liana Scognamiglio; Concetta Di Natale; Marilisa Leone; Roberta Cascella; Cristina Cecchi; Lisa Lirussi; Giulia Antoniali; Domenico Riccardi; Giancarlo Morelli; Gianluca Tell; Fabrizio Chiti; Daniela Marasco | |
| Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations | 2016 | Cappelli, S; Penco, A; Mannini, Benedetta; Cascella, Roberta; Wilson, M; Ecroyd, H; Li, X; Buxbaum, J; Dobson, Cm; Cecchi, Cristina; Relini, A; Chiti, Fabrizio | |
| Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies | 2022 | Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi | |
| Exploring the Aβ1-42 fibrillogenesis timeline by atomic force microscopy and surface enhanced Raman spectroscopy | 2024 | Panagis Polykretis, Cristiano D'Andrea, Martina Banchelli, Liliana Napolitano, Roberta Cascella, Marella de Angelis, Paolo Matteini |