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Exceptional thermal stability of carbonic acid-rich very high-density amorphous ice

: Similar to water ice, clathrate hydrates also undergo amorphization under increasing pressure at low temperature. This phenomenon was also recently reported for carbon dioxide (CO2) clathrate hydrate and identified as a crucial step for triggering the formation of carbonic acid (H2CO3) molecules and their subsequent arrangement into different crystalline polymorphs upon heating. Here, we present a combined x-ray diffraction and Raman study of the amorphization of CO2 clathrate hydrate into ...

Clinical Course and Predictors of Heart Failure in Asymptomatic Obstructive Hypertrophic Cardiomyopathy

BACKGROUND: Left ventricular outflow tract obstruction is a major contributor to morbidity in hypertrophic cardiomyopathy and an established therapeutic target. However, the risk factors driving progression to symptomatic heart failure in asymptomatic patients with obstructive hypertrophic cardiomyopathy remain incompletely understood. METHODS: We retrospectively identified 341 consecutive asymptomatic patients with obstructive hypertrophic cardiomyopathy (New York Heart Association class I, ...

Atrial fibrillation in hypertrophic cardiomyopathy: A unique clinical entity requiring dedicated study

Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM) occurring in 20%-25% of patients and associated with significant morbidity including stroke risk and worsening heart failure. AF in HCM (HCM-AF) arises from disease-specific mechanisms distinct from non-HCM-AF, including HCM-related atrial structural changes (dilation/fibrosis), biophysical abnormalities (within ion-channels), and atrial dysfunction that culminate in an HCM-specific atrial my...

Long-term mavacamten exposure reduces force and sarcomere density in a human induced pluripotent stem cell-derived model of hypertrophic cardiomyopathy

We investigated the structural and functional consequences of chronic mavacamten exposure using human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) and engineered heart tissues (EHTs) generated from an HCM MYBPC3:c.772G A hiPSC line (ID3)

Fetal Right Ventricular Dilatation and Dysfunction as a Precursor of Dilated Cardiomyopathy: A Diagnostic Pitfall and a Call for Vigilance

We hypothesize that RV dilatation in utero may represent a red flag for myocardial frailty in the context of a genetic predisposition to DCM, which may become clinically overt following the transition to adult circulation. These observations expand the clinical spectrum of RV dilatation in the fetus and warrant specific surveillance to exclude early-onset DCM during follow-up.

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