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Productions and Producers of Terra Sigillata at Cosa (Ansedonia, GR) Between Past and Recent Research

Aggiornamenti sulla produzione ceramica circolante a Cosa in età imperiale, tra i nuovi scavi dell'Università di Firenze e i vecchi lavori dell'American Academy of Rome.

Navigating TIPS in the era of ageing and metabolic comorbidity: a contemporary narrative review of risk, resilience, and outcomes

The ageing of the cirrhotic population, together with the epidemiological shift toward metabolic dysfunction-associated steatohepatitis, is redefining the profile of patients referred for transjugular intrahepatic portosystemic shunt (TIPS). Although TIPS remains a cornerstone in the management of complications of portal hypertension, its abrupt hemodynamic and metabolic effects challenge the physiological reserve of multiple organ systems. Age-related cardiovascular remodeling, cirrhotic car...

Broadband THz time-domain spectroscopy of water: Enhanced cooperativity of hydrogen-bond dynamics in the Debye wing

Broadband terahertz time-domain spectroscopy measurements of liquid water are presented in the 0.3–12 THz frequency range from 360 K down to the supercooled regime at 255 K. The probed spectral window allows the characterization of the intermediate-frequency region linking the main Debye relaxation to intermolecular vibrational modes. The dielectric response is analysed using two alternative fitting schemes, yielding consistent fits despite the different parametrizations. Upon cooling, the di...

Metabolic dysfunction-associated steatotic adrenal disease: a new entity in MetS, an experimental study in rabbits

Purpose: High-fat diets (HFDs) are major drivers of metabolic alterations (obesity, insulin resistance, and hypertension). Although hypertension is a hallmark of metabolic syndrome (MetS), the involvement of adrenals remains underexplored. This study investigates the morpho-functional alterations of the adrenals in a rabbit model of HFD-induced MetS. Methods: Adult rabbits were fed either a regular diet (RD) or a high-fat diet (HFD) for 12 weeks. Adrenal glands were harvested for subsequent a...

Casein Kinase 2 Inhibitor, CX-4945, Induces Apoptosis and Restores Blood-Brain Barrier Homeostasis in In Vitro and In Vivo Models of Glioblastoma

Background: In oncology, casein kinase 2 (CK2), a serine/threonine kinase, has a dual action, regulating cellular processes and acting as an oncogenic promoter. Methods: This study examined the effect of CX-4945, a selective CK2 inhibitor, in a human U-87 glioblastoma (GBM) cell line, treated with CX-4945 (5, 10, and 15 μM) for 24 h. Similarly, the hCMEC/D3 cell line was used to mimic the blood–brain barrier (BBB), examining the ability of CX-4945 to restore BBB homeostasis, after stimulation...

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Prodotti recenti

Productions and Producers of Terra Sigillata at Cosa (Ansedonia, GR) Between Past and Recent Research

Navigating TIPS in the era of ageing and metabolic comorbidity: a contemporary narrative review of risk, resilience, and outcomes

Broadband THz time-domain spectroscopy of water: Enhanced cooperativity of hydrogen-bond dynamics in the Debye wing

Metabolic dysfunction-associated steatotic adrenal disease: a new entity in MetS, an experimental study in rabbits

Casein Kinase 2 Inhibitor, CX-4945, Induces Apoptosis and Restores Blood-Brain Barrier Homeostasis in In Vitro and In Vivo Models of Glioblastoma

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