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Role of the exopolysaccharide levan in the life cycle of Pseudomonas syringae pv. actinidiae biovar 3, a phytopathogenic member of the bacterial community of Pseudomonas sp. associated with kiwifruit

The spread of plant pathogens represents a growing threat to global agriculture, particularly in the context of changing environmental conditions. Among these, Pseudomonas syringae pv. actinidiae biovar 3 (Psa3), the causal agent of bacterial canker of kiwifruit, represents one of the most significant threats to kiwifruit production worldwide. The success of this pathogen is probably closely linked to its ability to adapt to fluctuating environmental conditions and to persist on plant surface...

NS2B-NS3 protease as a target for anti-flaviviral therapeutics: Expression and NMR assignment of proteins from pathogenic strains for drug screening

Flaviviruses are associated with widespread human infections, and their incidence in the northern hemisphere has increased in recent years. Despite their significant clinical impact, there are currently no small molecule therapeutics available for the most representative viruses such as Zika virus (ZIKV), dengue virus (DENV), and West Nile virus (WNV) [1]. The viral genome encodes a polyprotein precursor that is subsequently processed by both viral and host proteases into functional units. A ...

Non-Covalent N-Glycan-Directed Paramagnetic Tagging: Structural Analysis of Glycoproteins by NMR

Paramagnetic probes have become powerful tools in structural biology, providing access to long-range structural information in biomolecular systems1. However, the success of these approaches relies on the precise positioning of the paramagnetic centre relative to the biomolecular surface, which is commonly achieved through covalent protein modification. Although effective, this strategy often requires extensive protein engineering and may perturb the native structure of the system2. Consequen...

Decoupling geogenic and bioclimatic drivers of global microbial niches: A machine learning framework for the genus Rubrobacter

Understanding the macroecological distribution of extremophiles requires separating bioclimatic variables from geological drivers. We present a biogeochemical and Machine Learning (ML) framework mapping the global abundance distribution of the radiation-resistant genus Rubrobacter across 76 soil metagenomes. By combining satellite remote sensing with isotope geochemistry, we developed an Aridity-Alkalinity Index (AAI) to isolate deep geogenic tracers. Models show that Rubrobacter is constrain...

Reply to: On the use of seismic noise studies for landslide rock block hazard assessment

This reply is intended to address the main concerns raised in the matters arising by Bottelin et al.1 to more clearly describe the use of fixed boundary conditions adopted in ref. 2, to underline limitations in the approach, and to discuss how alternative boundary conditions and block geometries might influence the system’s dynamics (see the Session “Numerical simulation limitations”).

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Prodotti recenti

Role of the exopolysaccharide levan in the life cycle of Pseudomonas syringae pv. actinidiae biovar 3, a phytopathogenic member of the bacterial community of Pseudomonas sp. associated with kiwifruit

NS2B-NS3 protease as a target for anti-flaviviral therapeutics: Expression and NMR assignment of proteins from pathogenic strains for drug screening

Non-Covalent N-Glycan-Directed Paramagnetic Tagging: Structural Analysis of Glycoproteins by NMR

Decoupling geogenic and bioclimatic drivers of global microbial niches: A machine learning framework for the genus Rubrobacter

Reply to: On the use of seismic noise studies for landslide rock block hazard assessment

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