FALSINI, MATTEO
FALSINI, MATTEO
Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)
2-Aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as new potent adenosine human A2A receptor antagonists
2016 Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Dal Ben, D.; Marucci, G.; Buccioni, M.; Volpini, R.; De Vita, T.; Colotta, V. .
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII
2017 Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Tanc, Muhammet; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII.
2015 Squarcialupi, L.; Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Di Cesare Mannelli, L.; Zanardelli, M.; Ghelardini, C.; Tanc, M.; Supuran, C.T.; Colotta, V.
Aminopyridine-3,5-carbonitrile core for the design of new adenosine receptor agonists: structural exploration to target the A1 subtype
2016 Betti, M.; Colotta, V.; Varano, F.; Falsini, M.; Varani, K.; Vincenzi, F.; Dal Ben, D.; Di Cesare Mannelli, L.; Zanardelli, M.; Bartolucci, G.; Menicatti, M.; Catarzi, D.
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain
2019 Falsini M.; Catarzi D.; Varano F.; Ceni C.; Dal Ben D.; Marucci G.; Buccioni M.; Volpini R.; Di Cesare Mannelli L.; Lucarini E.; Ghelardini C.; Bartolucci G.; Menicatti M.; Colotta V.
Design and synthesis of new adenosine receptor antagonists as neuroprotective agents
2019 matteo falsini
Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity
2016 Flavia Varano; Daniela Catarzi; Fabrizio Vincenzi; Marco Betti; Matteo Falsini; Annalisa Ravani; Pier Andrea Borea; Vittoria Colotta; Katia Varani
Development of novel pyridazinone-based adenosine receptor ligands
2018 Daniela Catarzi , Flavia Varano, Matteo Falsini , Katia Varani, Fabrizio Vincenzi , Silvia Pasquini , Diego Dal Ben, Vittoria Colotta
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors
2016 Lucia Squarcialupi; Matteo Falsini; Daniela Catarzi; Flavia Varano; Marco Betti; Katia Varani; Fabrizio Vincenzi; Diego Dal Ben; Catia Lambertucci; Rosaria Volpini; Vittoria Colotta
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1and A2Aadenosine receptor antagonists/inverse agonists
2018 Varano, Flavia*; Catarzi, Daniela; Falsini, Matteo; Vincenzi, Fabrizio; Pasquini, Silvia; Varani, Katia; Colotta, Vittoria
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes
2017 Daniela Poli, ; Matteo Falsini, ; Flavia Varano, ; Marco Betti, ; Katia Varani, ; Fabrizio Vincenzi, ; Anna Maria Pugliese, ; Felicita Pedata, ; Diego Dal Ben, ; Ajiroghene Thomas, ; Ilaria Palchetti, ; Francesca Bettazzi, ; Daniela Catarzi, ; Colotta, Vittoria
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity
2019 Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Lucarini, Elena; Dal Ben, Diego; Spinaci, Andrea; Bartolucci, Gian Luca; Menicatti, Marta; Colotta, Vittoria
New 5-heteroaryl-pyrazolo[4,3-d]pyrimidin-7-amines as dual human adenosine A1 and A2A receptor antagonists.
2016 Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Lambertucci, Catia; Volpini, Rosaria; Colotta, Vittoria
New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists
2020 Falsini M.; Ceni C.; Catarzi D.; Varano F.; Dal Ben D.; Marucci G.; Buccioni M.; Marti Navia A.; Volpini R.; Colotta V.
New aminopyridine-3,5-dicarbonitirles as adenosine A2B receptor non-nucleoside agonists.
2016 Betti, Marco; Colotta, Vittoria; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Pugliese, Annamaria; Catarzi, Daniela
Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells
2019 Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Dal Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Colotta, Vittoria*
Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity
2019 Varano, Flavia*; Catarzi, Daniela; Falsini, Matteo; Dal Ben, Diego; Buccioni, Michela; Marucci, Gabriella; Volpini, Rosaria; Colotta, Vittoria
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII
2018 Bonardi, Alessandro; Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria*
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor
2016 Lucia Squarcialupi ; Daniela Catarzi ; Flavia Varano; Marco Betti; Matteo Falsini; Fabrizio Vincenzi ; Annalisa Ravani; Antonella Ciancetta ; Katia Varani ; Stefano Moro; Vittoria Colotta
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor
2018 Varano, Flavia*; Catarzi, Daniela; Vincenzi, Fabrizio; Falsini, Matteo; Pasquini, Silvia; Borea, Pier Andrea; Colotta, Vittoria; Varani, Katia
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 2-Aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as new potent adenosine human A2A receptor antagonists | 2016 | Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Dal Ben, D.; Marucci, G.; Buccioni, M.; Volpini, R.; De Vita, T.; Colotta, V. . | |
| 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII | 2017 | Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Tanc, Muhammet; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria | |
| 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII. | 2015 | Squarcialupi, L.; Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Di Cesare Mannelli, L.; Zanardelli, M.; Ghelardini, C.; Tanc, M.; Supuran, C.T.; Colotta, V. | |
| Aminopyridine-3,5-carbonitrile core for the design of new adenosine receptor agonists: structural exploration to target the A1 subtype | 2016 | Betti, M.; Colotta, V.; Varano, F.; Falsini, M.; Varani, K.; Vincenzi, F.; Dal Ben, D.; Di Cesare Mannelli, L.; Zanardelli, M.; Bartolucci, G.; Menicatti, M.; Catarzi, D. | |
| Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain | 2019 | Falsini M.; Catarzi D.; Varano F.; Ceni C.; Dal Ben D.; Marucci G.; Buccioni M.; Volpini R.; Di Cesare Mannelli L.; Lucarini E.; Ghelardini C.; Bartolucci G.; Menicatti M.; Colotta V. | |
| Design and synthesis of new adenosine receptor antagonists as neuroprotective agents | 2019 | matteo falsini | |
| Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity | 2016 | Flavia Varano; Daniela Catarzi; Fabrizio Vincenzi; Marco Betti; Matteo Falsini; Annalisa Ravani; Pier Andrea Borea; Vittoria Colotta; Katia Varani | |
| Development of novel pyridazinone-based adenosine receptor ligands | 2018 | Daniela Catarzi , Flavia Varano, Matteo Falsini , Katia Varani, Fabrizio Vincenzi , Silvia Pasquini , Diego Dal Ben, Vittoria Colotta | |
| Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors | 2016 | Lucia Squarcialupi; Matteo Falsini; Daniela Catarzi; Flavia Varano; Marco Betti; Katia Varani; Fabrizio Vincenzi; Diego Dal Ben; Catia Lambertucci; Rosaria Volpini; Vittoria Colotta | |
| Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1and A2Aadenosine receptor antagonists/inverse agonists | 2018 | Varano, Flavia*; Catarzi, Daniela; Falsini, Matteo; Vincenzi, Fabrizio; Pasquini, Silvia; Varani, Katia; Colotta, Vittoria | |
| Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes | 2017 | Daniela Poli, ; Matteo Falsini, ; Flavia Varano, ; Marco Betti, ; Katia Varani, ; Fabrizio Vincenzi, ; Anna Maria Pugliese, ; Felicita Pedata, ; Diego Dal Ben, ; Ajiroghene Thomas, ; Ilaria Palchetti, ; Francesca Bettazzi, ; Daniela Catarzi, ; Colotta, Vittoria | |
| Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity | 2019 | Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Lucarini, Elena; Dal Ben, Diego; Spinaci, Andrea; Bartolucci, Gian Luca; Menicatti, Marta; Colotta, Vittoria | |
| New 5-heteroaryl-pyrazolo[4,3-d]pyrimidin-7-amines as dual human adenosine A1 and A2A receptor antagonists. | 2016 | Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Lambertucci, Catia; Volpini, Rosaria; Colotta, Vittoria | |
| New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists | 2020 | Falsini M.; Ceni C.; Catarzi D.; Varano F.; Dal Ben D.; Marucci G.; Buccioni M.; Marti Navia A.; Volpini R.; Colotta V. | |
| New aminopyridine-3,5-dicarbonitirles as adenosine A2B receptor non-nucleoside agonists. | 2016 | Betti, Marco; Colotta, Vittoria; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Pugliese, Annamaria; Catarzi, Daniela | |
| Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells | 2019 | Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Dal Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Colotta, Vittoria* | |
| Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity | 2019 | Varano, Flavia*; Catarzi, Daniela; Falsini, Matteo; Dal Ben, Diego; Buccioni, Michela; Marucci, Gabriella; Volpini, Rosaria; Colotta, Vittoria | |
| Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII | 2018 | Bonardi, Alessandro; Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria* | |
| Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor | 2016 | Lucia Squarcialupi ; Daniela Catarzi ; Flavia Varano; Marco Betti; Matteo Falsini; Fabrizio Vincenzi ; Annalisa Ravani; Antonella Ciancetta ; Katia Varani ; Stefano Moro; Vittoria Colotta | |
| Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor | 2018 | Varano, Flavia*; Catarzi, Daniela; Vincenzi, Fabrizio; Falsini, Matteo; Pasquini, Silvia; Borea, Pier Andrea; Colotta, Vittoria; Varani, Katia |