BONARDI, ALESSANDRO
BONARDI, ALESSANDRO
Neuroscienze, Area del Farmaco e Salute del Bambino (NEUROFARBA)
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop
2022 Arias, Hugo R; Borghese, Cecilia M; Germann, Allison L; Pierce, Spencer R; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Thodati, Thanvi M; Lim, Natalie J; Harris, R Adron; Akk, Gustav
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity
2022 Chiaramonte N.; Angeli A.; Sgambellone S.; Bonardi A.; Nocentini A.; Bartolucci G.; Braconi L.; Dei S.; Lucarini L.; Teodori E.; Gratteri P.; Wunsch B.; Supuran C.T.; Romanelli M.N.
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.
2018 Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni, Alessio Nocentini, Alessandro Bonardi, Gian Luca Bartolucci, Maria Concetta Durante, Laura Lucarini, Donata Chiapponi, Silvia Dei, Dina Manetti, Elisabetta Teodori, Paola Gratteri, Emanuela Masini, Claudiu T. Supuran, Maria Novella Romanelli
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights
2019 Abo-Ashour M.F.; Eldehna W.M.; Nocentini A.; Bonardi A.; Bua S.; Ibrahim H.S.; Elaasser M.M.; Krystof V.; Jorda R.; Gratteri P.; Abou-Seri S.M.; Supuran C.T.
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies
2020 Alkhaldi A.A.M.; Al-Sanea M.M.; Nocentini A.; Eldehna W.M.; Elsayed Z.M.; Bonardi A.; Abo-Ashour M.F.; El-Damasy A.K.; Abdel-Maksoud M.S.; Al-Warhi T.; Gratteri P.; Abdel-Aziz H.A.; Supuran C.T.; El-Haggar R.
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments
2023 Ragab, Mahmoud A; Eldehna, Wagdy M; Nocentini, Alessio; Bonardi, Alessandro; Okda, Hazem E; Elgendy, Bahaa; Ibrahim, Tarek S; Abd-Alhaseeb, Mohammad M; Gratteri, Paola; Supuran, Claudiu T; Al-Karmalawy, Ahmed A; Elagawany, Mohamed
4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors
2023 Abdoli, Morteza; Bonardi, Alessandro; Supuran, Claudiu T; Žalubovskis, Raivis
A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors
2022 Banoglu, Erden; Ercanlı, Taner; Gür Maz, Tuğçe; Vullo, Daniela; Bonardi, Alessandro; Gratteri, Paola; Supuran, Claudiu T
Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae
2020 Bonardi A.; Nocentini A.; Cadoni R.; Del Prete S.; Dumy P.; Capasso C.; Gratteri P.; Supuran C.T.; Winum J.-Y.
Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition
2022 Sbravati D.; Bonardi A.; Bua S.; Angeli A.; Ferraroni M.; Nocentini A.; Casnati A.; Gratteri P.; Sansone F.; Supuran C.T.
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats
2021 Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L.
Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents.
2019 Alessandro Bonardi, Paola Gratteri, Alessio Nocentini
Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris
2022 Aspatwar, Ashok; Barker, Harlan; Aisala, Heidi; Zueva, Ksenia; Kuuslahti, Marianne; Tolvanen, Martti; Primmer, Craig R; Lumme, Jaakko; Bonardi, Alessandro; Tripathi, Amit; Parkkila, Seppo; Supuran, Claudiu T
Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents
2022 Tawfik, Haytham O; Belal, Amany; Abourehab, Mohammed A S; Angeli, Andrea; Bonardi, Alessandro; Supuran, Claudiu T; El-Hamamsy, Mervat H
Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII
2022 Al-Warhi, Tarfah; Elbadawi, Mostafa M; Bonardi, Alessandro; Nocentini, Alessio; Al-Karmalawy, Ahmed A; Aljaeed, Nada; Alotaibi, Ohoud J; Abdel-Aziz, Hatem A; Supuran, Claudiu T; Eldehna, Wagdy M
Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis
2022 Bonardi, Alessandro; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
2023 Giovannuzzi, Simone; Bonardi, Alessandro; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T
Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides
2023 Angeli A.; Ferraroni M.; Bonardi A.; Supuran C.T.; Nocentini A.
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform
2018 Ibrahim, Hany S.*; Allam, Heba Abdelrasheed; Mahmoud, Walaa R.; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Ibrahim, Eslam S.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents
2019 Eldehna, Wagdy M.*; Abo-Ashour, Mahmoud F.; Nocentini, Alessio; El-Haggar, Radwan S.; Bua, Silvia; Bonardi, Alessandro; Al-Rashood, Sara T.; Hassan, Ghada S.; Gratteri, Paola; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| (+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop | 2022 | Arias, Hugo R; Borghese, Cecilia M; Germann, Allison L; Pierce, Spencer R; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Thodati, Thanvi M; Lim, Natalie J; Harris, R Adron; Akk, Gustav | |
| 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity | 2022 | Chiaramonte N.; Angeli A.; Sgambellone S.; Bonardi A.; Nocentini A.; Bartolucci G.; Braconi L.; Dei S.; Lucarini L.; Teodori E.; Gratteri P.; Wunsch B.; Supuran C.T.; Romanelli M.N. | |
| 2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. | 2018 | Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni, Alessio Nocentini, Alessandro Bonardi, Gian Luca Bartolucci, Maria Concetta Durante, Laura Lucarini, Donata Chiapponi, Silvia Dei, Dina Manetti, Elisabetta Teodori, Paola Gratteri, Emanuela Masini, Claudiu T. Supuran, Maria Novella Romanelli | |
| 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights | 2019 | Abo-Ashour M.F.; Eldehna W.M.; Nocentini A.; Bonardi A.; Bua S.; Ibrahim H.S.; Elaasser M.M.; Krystof V.; Jorda R.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. | |
| 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies | 2020 | Alkhaldi A.A.M.; Al-Sanea M.M.; Nocentini A.; Eldehna W.M.; Elsayed Z.M.; Bonardi A.; Abo-Ashour M.F.; El-Damasy A.K.; Abdel-Maksoud M.S.; Al-Warhi T.; Gratteri P.; Abdel-Aziz H.A.; Supuran C.T.; El-Haggar R. | |
| 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments | 2023 | Ragab, Mahmoud A; Eldehna, Wagdy M; Nocentini, Alessio; Bonardi, Alessandro; Okda, Hazem E; Elgendy, Bahaa; Ibrahim, Tarek S; Abd-Alhaseeb, Mohammad M; Gratteri, Paola; Supuran, Claudiu T; Al-Karmalawy, Ahmed A; Elagawany, Mohamed | |
| 4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors | 2023 | Abdoli, Morteza; Bonardi, Alessandro; Supuran, Claudiu T; Žalubovskis, Raivis | |
| A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors | 2022 | Banoglu, Erden; Ercanlı, Taner; Gür Maz, Tuğçe; Vullo, Daniela; Bonardi, Alessandro; Gratteri, Paola; Supuran, Claudiu T | |
| Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae | 2020 | Bonardi A.; Nocentini A.; Cadoni R.; Del Prete S.; Dumy P.; Capasso C.; Gratteri P.; Supuran C.T.; Winum J.-Y. | |
| Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition | 2022 | Sbravati D.; Bonardi A.; Bua S.; Angeli A.; Ferraroni M.; Nocentini A.; Casnati A.; Gratteri P.; Sansone F.; Supuran C.T. | |
| Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats | 2021 | Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L. | |
| Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents. | 2019 | Alessandro Bonardi, Paola Gratteri, Alessio Nocentini | |
| Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris | 2022 | Aspatwar, Ashok; Barker, Harlan; Aisala, Heidi; Zueva, Ksenia; Kuuslahti, Marianne; Tolvanen, Martti; Primmer, Craig R; Lumme, Jaakko; Bonardi, Alessandro; Tripathi, Amit; Parkkila, Seppo; Supuran, Claudiu T | |
| Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents | 2022 | Tawfik, Haytham O; Belal, Amany; Abourehab, Mohammed A S; Angeli, Andrea; Bonardi, Alessandro; Supuran, Claudiu T; El-Hamamsy, Mervat H | |
| Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII | 2022 | Al-Warhi, Tarfah; Elbadawi, Mostafa M; Bonardi, Alessandro; Nocentini, Alessio; Al-Karmalawy, Ahmed A; Aljaeed, Nada; Alotaibi, Ohoud J; Abdel-Aziz, Hatem A; Supuran, Claudiu T; Eldehna, Wagdy M | |
| Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis | 2022 | Bonardi, Alessandro; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T | |
| Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors | 2023 | Giovannuzzi, Simone; Bonardi, Alessandro; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T | |
| Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides | 2023 | Angeli A.; Ferraroni M.; Bonardi A.; Supuran C.T.; Nocentini A. | |
| Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform | 2018 | Ibrahim, Hany S.*; Allam, Heba Abdelrasheed; Mahmoud, Walaa R.; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Ibrahim, Eslam S.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. | |
| Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents | 2019 | Eldehna, Wagdy M.*; Abo-Ashour, Mahmoud F.; Nocentini, Alessio; El-Haggar, Radwan S.; Bua, Silvia; Bonardi, Alessandro; Al-Rashood, Sara T.; Hassan, Ghada S.; Gratteri, Paola; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. |