BONARDI, ALESSANDRO
BONARDI, ALESSANDRO
Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop
2022 Arias, Hugo R; Borghese, Cecilia M; Germann, Allison L; Pierce, Spencer R; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Thodati, Thanvi M; Lim, Natalie J; Harris, R Adron; Akk, Gustav
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity
2022 Chiaramonte N.; Angeli A.; Sgambellone S.; Bonardi A.; Nocentini A.; Bartolucci G.; Braconi L.; Dei S.; Lucarini L.; Teodori E.; Gratteri P.; Wunsch B.; Supuran C.T.; Romanelli M.N.
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.
2018 Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni, Alessio Nocentini, Alessandro Bonardi, Gian Luca Bartolucci, Maria Concetta Durante, Laura Lucarini, Donata Chiapponi, Silvia Dei, Dina Manetti, Elisabetta Teodori, Paola Gratteri, Emanuela Masini, Claudiu T. Supuran, Maria Novella Romanelli
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights
2019 Abo-Ashour M.F.; Eldehna W.M.; Nocentini A.; Bonardi A.; Bua S.; Ibrahim H.S.; Elaasser M.M.; Krystof V.; Jorda R.; Gratteri P.; Abou-Seri S.M.; Supuran C.T.
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies
2020 Alkhaldi A.A.M.; Al-Sanea M.M.; Nocentini A.; Eldehna W.M.; Elsayed Z.M.; Bonardi A.; Abo-Ashour M.F.; El-Damasy A.K.; Abdel-Maksoud M.S.; Al-Warhi T.; Gratteri P.; Abdel-Aziz H.A.; Supuran C.T.; El-Haggar R.
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments
2023 Ragab, Mahmoud A; Eldehna, Wagdy M; Nocentini, Alessio; Bonardi, Alessandro; Okda, Hazem E; Elgendy, Bahaa; Ibrahim, Tarek S; Abd-Alhaseeb, Mohammad M; Gratteri, Paola; Supuran, Claudiu T; Al-Karmalawy, Ahmed A; Elagawany, Mohamed
4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors
2023 Abdoli, Morteza; Krasniqi, Vesa; Bonardi, Alessandro; Gütschow, Michael; Supuran, Claudiu T; Žalubovskis, Raivis
4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors
2023 Abdoli, Morteza; Bonardi, Alessandro; Supuran, Claudiu T; Žalubovskis, Raivis
6-Aminocoumarin oxime-ether/sulfonamides as selective hCA IX and XII inhibitors: Synthesis, evaluation, and molecular dynamics studies
2023 Ghouse, Shaik Mahammad; Sinha, Kareena; Bonardi, Alessandro; Pawar, Gaurav; Malasala, Satyaveni; Danaboina, Srikanth; Mohammed, Arifuddin; Yaddanapudi, Venkata M; Supuran, Claudiu T; Nanduri, Srinivas
6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography
2023 Nocentini, Alessio; Bonardi, Alessandro; Bazzicalupi, Carla; Alterio, Vincenzo; Esposito, Davide; Monti, Simona Maria; Smietana, Michael; De Simone, Giuseppina; Supuran, Claudiu T; Gratteri, Paola; Winum, Jean-Yves
A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors
2022 Banoglu, Erden; Ercanlı, Taner; Gür Maz, Tuğçe; Vullo, Daniela; Bonardi, Alessandro; Gratteri, Paola; Supuran, Claudiu T
Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant Mycobacterium tuberculosis Strains
2024 Bua, Silvia; Bonardi, Alessandro; Mük, Georgiana Ramona; Nocentini, Alessio; Gratteri, Paola; Supuran, Claudiu T.
Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity
2024 Giovannuzzi S.; Nikitjuka A.; Angeli A.; Smietana M.; Massardi M.-L.; Turati M.; Ronca R.; Bonardi A.; Nocentini A.; Ferraroni M.; Supuran C.T.; Winum J.-Y.
Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae
2020 Bonardi A.; Nocentini A.; Cadoni R.; Del Prete S.; Dumy P.; Capasso C.; Gratteri P.; Supuran C.T.; Winum J.-Y.
Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition
2022 Sbravati D.; Bonardi A.; Bua S.; Angeli A.; Ferraroni M.; Nocentini A.; Casnati A.; Gratteri P.; Sansone F.; Supuran C.T.
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats
2021 Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L.
Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents.
2019 Alessandro Bonardi, Paola Gratteri, Alessio Nocentini
Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris
2022 Aspatwar, Ashok; Barker, Harlan; Aisala, Heidi; Zueva, Ksenia; Kuuslahti, Marianne; Tolvanen, Martti; Primmer, Craig R; Lumme, Jaakko; Bonardi, Alessandro; Tripathi, Amit; Parkkila, Seppo; Supuran, Claudiu T
Computational approaches in drug discovery: strategies to address polypharmacology and the synthesis/optimization of lead compounds
2025 Niccolò Paoletti, Paola Gratteri, Claudiu T. Supuran, Alessandro Bonardi,
Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents
2022 Tawfik, Haytham O; Belal, Amany; Abourehab, Mohammed A S; Angeli, Andrea; Bonardi, Alessandro; Supuran, Claudiu T; El-Hamamsy, Mervat H
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| (+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop | 2022 | Arias, Hugo R; Borghese, Cecilia M; Germann, Allison L; Pierce, Spencer R; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Thodati, Thanvi M; Lim, Natalie J; Harris, R Adron; Akk, Gustav | |
| 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity | 2022 | Chiaramonte N.; Angeli A.; Sgambellone S.; Bonardi A.; Nocentini A.; Bartolucci G.; Braconi L.; Dei S.; Lucarini L.; Teodori E.; Gratteri P.; Wunsch B.; Supuran C.T.; Romanelli M.N. | |
| 2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. | 2018 | Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni, Alessio Nocentini, Alessandro Bonardi, Gian Luca Bartolucci, Maria Concetta Durante, Laura Lucarini, Donata Chiapponi, Silvia Dei, Dina Manetti, Elisabetta Teodori, Paola Gratteri, Emanuela Masini, Claudiu T. Supuran, Maria Novella Romanelli | |
| 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights | 2019 | Abo-Ashour M.F.; Eldehna W.M.; Nocentini A.; Bonardi A.; Bua S.; Ibrahim H.S.; Elaasser M.M.; Krystof V.; Jorda R.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. | |
| 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies | 2020 | Alkhaldi A.A.M.; Al-Sanea M.M.; Nocentini A.; Eldehna W.M.; Elsayed Z.M.; Bonardi A.; Abo-Ashour M.F.; El-Damasy A.K.; Abdel-Maksoud M.S.; Al-Warhi T.; Gratteri P.; Abdel-Aziz H.A.; Supuran C.T.; El-Haggar R. | |
| 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments | 2023 | Ragab, Mahmoud A; Eldehna, Wagdy M; Nocentini, Alessio; Bonardi, Alessandro; Okda, Hazem E; Elgendy, Bahaa; Ibrahim, Tarek S; Abd-Alhaseeb, Mohammad M; Gratteri, Paola; Supuran, Claudiu T; Al-Karmalawy, Ahmed A; Elagawany, Mohamed | |
| 4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors | 2023 | Abdoli, Morteza; Krasniqi, Vesa; Bonardi, Alessandro; Gütschow, Michael; Supuran, Claudiu T; Žalubovskis, Raivis | |
| 4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors | 2023 | Abdoli, Morteza; Bonardi, Alessandro; Supuran, Claudiu T; Žalubovskis, Raivis | |
| 6-Aminocoumarin oxime-ether/sulfonamides as selective hCA IX and XII inhibitors: Synthesis, evaluation, and molecular dynamics studies | 2023 | Ghouse, Shaik Mahammad; Sinha, Kareena; Bonardi, Alessandro; Pawar, Gaurav; Malasala, Satyaveni; Danaboina, Srikanth; Mohammed, Arifuddin; Yaddanapudi, Venkata M; Supuran, Claudiu T; Nanduri, Srinivas | |
| 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography | 2023 | Nocentini, Alessio; Bonardi, Alessandro; Bazzicalupi, Carla; Alterio, Vincenzo; Esposito, Davide; Monti, Simona Maria; Smietana, Michael; De Simone, Giuseppina; Supuran, Claudiu T; Gratteri, Paola; Winum, Jean-Yves | |
| A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors | 2022 | Banoglu, Erden; Ercanlı, Taner; Gür Maz, Tuğçe; Vullo, Daniela; Bonardi, Alessandro; Gratteri, Paola; Supuran, Claudiu T | |
| Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant Mycobacterium tuberculosis Strains | 2024 | Bua, Silvia; Bonardi, Alessandro; Mük, Georgiana Ramona; Nocentini, Alessio; Gratteri, Paola; Supuran, Claudiu T. | |
| Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity | 2024 | Giovannuzzi S.; Nikitjuka A.; Angeli A.; Smietana M.; Massardi M.-L.; Turati M.; Ronca R.; Bonardi A.; Nocentini A.; Ferraroni M.; Supuran C.T.; Winum J.-Y. | |
| Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae | 2020 | Bonardi A.; Nocentini A.; Cadoni R.; Del Prete S.; Dumy P.; Capasso C.; Gratteri P.; Supuran C.T.; Winum J.-Y. | |
| Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition | 2022 | Sbravati D.; Bonardi A.; Bua S.; Angeli A.; Ferraroni M.; Nocentini A.; Casnati A.; Gratteri P.; Sansone F.; Supuran C.T. | |
| Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats | 2021 | Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L. | |
| Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents. | 2019 | Alessandro Bonardi, Paola Gratteri, Alessio Nocentini | |
| Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris | 2022 | Aspatwar, Ashok; Barker, Harlan; Aisala, Heidi; Zueva, Ksenia; Kuuslahti, Marianne; Tolvanen, Martti; Primmer, Craig R; Lumme, Jaakko; Bonardi, Alessandro; Tripathi, Amit; Parkkila, Seppo; Supuran, Claudiu T | |
| Computational approaches in drug discovery: strategies to address polypharmacology and the synthesis/optimization of lead compounds | 2025 | Niccolò Paoletti, Paola Gratteri, Claudiu T. Supuran, Alessandro Bonardi, | |
| Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents | 2022 | Tawfik, Haytham O; Belal, Amany; Abourehab, Mohammed A S; Angeli, Andrea; Bonardi, Alessandro; Supuran, Claudiu T; El-Hamamsy, Mervat H |