We comment on a review illustrating the shortcomings of targeting at just the MSN lineage when trying to produce stem cells for a substitutive therapy to HD patients. We document recent and important insights emerged from studies by us and others, encompassing fetal striatal grafting and normal striatal development.
Stem cell-based regenerative medicine in Huntington’s disease: is fetal striatal grafting passing the baton? A commentary on “Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient” / B Porfirio; A Morelli; R Conti; GB Vannelli; P Gallina. - In: FRONTIERS IN CELLULAR NEUROSCIENCE. - ISSN 1662-5102. - ELETTRONICO. - 9:177:(2015), pp. 1-3. [10.3389/fncel.2015.00177]
Stem cell-based regenerative medicine in Huntington’s disease: is fetal striatal grafting passing the baton? A commentary on “Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient”
PORFIRIO, BERARDINO;MORELLI, ANNAMARIA;CONTI, RENATO;VANNELLI, GABRIELLA;GALLINA, PASQUALE
2015
Abstract
We comment on a review illustrating the shortcomings of targeting at just the MSN lineage when trying to produce stem cells for a substitutive therapy to HD patients. We document recent and important insights emerged from studies by us and others, encompassing fetal striatal grafting and normal striatal development.
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