Organs at risk in the brain and their dose-constraints in adults and in children: A radiation oncologist's guide for delineation in everyday practice.

Scoccianti, S.; Detti, B.; Gadda, D.; Greto, D.; Furfaro, I.; Meacci, F.; Simontacchi, G.; Di Brina, L.; Bonomo, P.; Giacomelli, I.; Meattini, Icro; Mangoni, Monica; Cappelli, S.; Cassani, S.; Talamonti, Cinzia; Bordi, L.; Livi, Lorenzo

doi:10.1016/j.radonc.2015.01.016

PURPOSE: Accurate organs at risk definition is essential for radiation treatment of brain tumors. The aim of this study is to provide a stepwise and simplified contouring guide to delineate the OARs in the brain as it would be done in the everyday practice of planning radiotherapy for brain cancer treatment. METHODS: Anatomical descriptions and neuroimaging atlases of the brain were studied. The dosimetric constraints used in literature were reviewed. RESULTS: A Computed Tomography and Magnetic Resonance Imaging based detailed atlas was developed jointly by radiation oncologists, a neuroradiologist and a neurosurgeon. For each organ brief anatomical notion, main radiological reference points and useful considerations are provided. Recommended dose-constraints both for adult and pediatric patients were also provided. CONCLUSIONS: This report provides guidelines for OARs delineation and their dose-constraints for the treatment planning of patients with brain tumors.

Organs at risk in the brain and their dose-constraints in adults and in children: A radiation oncologist's guide for delineation in everyday practice / Scoccianti S.; Detti B.; Gadda D.; Greto D.; Furfaro I.; Meacci F.; Simontacchi G.; Di Brina L.; Bonomo P.; Giacomelli I.; Meattini I.; Mangoni M.; Cappelli S.; Cassani S.; Talamonti C.; Bordi L.; Livi L.. - In: RADIOTHERAPY AND ONCOLOGY. - ISSN 0167-8140. - STAMPA. - 114:(2015), pp. 230-238. [10.1016/j.radonc.2015.01.016]