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Intermolecular interactions in biointerfaces: a blueprint for smart responsive materials

This work explores some fundamental yet often overlooked aspects of physicochemical interactions, such as intermolecular ones. In this framework, we begin by examining simple systems followed by more complex biointerfaces to obtain key insights, which are then applied to the design of smart, autonomous, multiresponsive soft materials. We began by examining the diffusion and aggregation behaviour of a prominent green solvent, glycerol carbonate (GC) in water, confirming its self-aggregation. ...

Integrating novel neuroimaging measurements and circulating biomarkers for the prediction of secondary injury following stroke. the NIMBLE study.

ABSTRACT INTRODUCTION Cerebral edema (CE) and haemorrhagic transformation (HT) induce brain swelling and represents the most feared complications of reperfusion injury in acute ischemic stroke. Haemorrhagic conversion is particularly concerning due to its potential for rapid clinical deterioration or mortality. Additionally, cerebral oedema, while less immediately alarming, can significantly impact patient outcomes. Optimizing the measurement of these complications and identifying early pre...

Geochemical Background and Baselines values of PTEs (Potentially Toxic Elements) in soils and stream sediments from decommissioned mining areas: the Hg-district of Mt. Amiata (central Italy)

This PhD thesis was aimed at evaluating mercury (Hg) contamination and other potentially toxic elements (PTEs) in soils and stream sediments from the eastern sector of the Mt Amiata district (central Italy), with a specific focus on the former mining area of Abbadia San Salvatore (ASS). In particular, the study area covers a rectangle of about 120 km2, where eight of the most important former Hg-mines in Italy and in the world are present. The region, historically a major global producer of H...

On problems involving second order differential inclusions in Banach spaces.

This thesis provides a contribution to the study of second order differential inclusions in abstract spaces, examining different types of problem. The proofs of the existence results are based on a combination of a fixed point methods with selection theorems and, where useful, on the utilization of the measure of weak noncompactness. The mentioned approach has the advantage of not requiring compactness assumptions on the operators and multivalued terms that characterize the differential incl...

Characterization of Tryptophan 2,3-dioxygenase in human melanoma cell lines and endothelial cells as a new therapeutic target

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are heme-enzymes involved in the degradation of tryptophan (Trp) into kynurenine (Kyn) within the kynurenine pathway (KP). While the role of IDO1 in cancer immune escape has been extensively studied, recent evidence suggests that TDO may also contribute to tumor progression, particularly in melanoma. This study aimed to characterize TDO expression and function in human melanoma cell lines and the tumor microenvironme...

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