8 - Tesi di dottorato

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8a - Tesi di dottorato 4497

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Chemical strategies to design precision therapeutics for cancer treatment

Tesi di dottorato in Scienze chimica (SSD CHEM05-A) basata sullo studio di nuovi approcci chimici per lo sviluppo di nuove terapia di precisione del cancro.

Morphology-aware atom depth calculation for protein stability analysis

This thesis contributes to the research on Siamese networks by presenting how they can be used to devise a soft estimation of the Graph–Edit Distance, which allows to solve the NP–complete graph isomorphism problem in an affordable time. Then, three distinct applications of Siamese networks are presented, related to two prediction and one classification tasks. In all of these applications, the embedding space is constructed based on the similarity target, without relying on the classical Siam...

Lactate-induced H3K18 lactylation drives prostate cancer aggressiveness through a GLO1-dependent lactyl-GSH pathway

This work unveils a GLO1-dependent pathway as a key contributor to lactate-mediated H3K18la and its downstream transcriptional outputs, highlighting histone lactylation as a metabolically driven regulator of prostate cancer progression and as a potential target for therapeutic intervention in lactate-enriched TME.

L'architettura dipinta negli affreschi di Giotto e dei giotteschi ad Assisi. Rilievo e interpretazione critica del ciclo delle Storie di San Francesco.

The representation of architectural space in painting has been a focus since Roman times, evolving with advances in perspective, optics, and geometry. After a decline following the fall of the Roman Empire, painted architecture reemerged in the late-communal and signorie periods, moving beyond Byzantine models to achieve autonomous volumetric consistency and interact meaningfully with figures. Giotto exemplifies this shift, creating spatially coherent buildings that actively contribute to the...

The Anti-Müllerian Hormone Receptor Type II (AMHR2): preliminary steps to unravel its potential as new non-gynaecological tumor antigen

In recent decades, interest in immunotherapy and the development of personalized cancer treatments has significantly increased. Monoclonal antibodies (mAbs) have emerged as powerful therapeutic tools due to their high specificity and ability to selectively recognize tumor-associated antigens (TAAs). The identification of novel membrane targets is therefore essential for improving targeted therapeutic strategies. In this context, this study investigated the anti-Müllerian hormone receptor type...

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