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8a - Tesi di dottorato 3975

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Characterization of Tryptophan 2,3-dioxygenase in human melanoma cell lines and endothelial cells as a new therapeutic target

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are heme-enzymes involved in the degradation of tryptophan (Trp) into kynurenine (Kyn) within the kynurenine pathway (KP). While the role of IDO1 in cancer immune escape has been extensively studied, recent evidence suggests that TDO may also contribute to tumor progression, particularly in melanoma. This study aimed to characterize TDO expression and function in human melanoma cell lines and the tumor microenvironme...

Geochemical study of air quality in areas affected by the addition of anthropogenic and natural contaminants

As societies face escalating challenges due to air pollution, this PhD research introduces a novel, integrated approach to air quality assessment, aimed at complementing and enhancing traditional monitoring methods. The approach addresses limitations in current practices, which struggle to keep pace with global demands for mitigation. This need is driven by factors such as (i) the dual role of urban and industrial areas as sources and targets of pollutants; (ii) increased populations living n...

Sperm oxidative status: methods of analysis, relation with semen parameters and ART outcomes

Infertility is defined by the World Health Organization (WHO) as the inability to conceive after 12 months of regular unprotected sexual intercourse. It is considered that oxidative stress (OS), defined as an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defences, may be a contributing factor in the aetiology of idiopathic infertility. The principal aim of my doctoral research was to evaluate the oxidative status of semen samples of male partners of inf...

Different immunophenotypes and cytokine profiles in non-systemic Juvenile Idiopathic Arthritis (JIA): potential fingerprints for predicting disease course and flare and driving therapeutic decisions.

Background: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in childhood and its prognosis has dramatically improved thanks to the novel treatments and the step forward performed in understanding the pathophysiology of the disease. However, contrasting data are available regarding clinical and laboratory predictors of response to treatment and relapse after drug withdrawal. Objectives: The purpose of the present study were to identify: 1. In a mu...

Phenotypic and genetic spectrum of ATP6V1A encephalopathy: a disorder of lysosomal homeostasis

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