The AID/APOBECs are deaminases that act on cytosines in a diverse set of pathways and some of them have been linked to the onset of genetic alterations in cancer. Among them, APOBEC1 is the only family member to physiologically target RNA, as the catalytic subunit in the Apolipoprotein B mRNA editing complex. APOBEC1 has been linked to cancer development in mice but its oncogenic mechanisms are not yet well understood.
The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas / Saraconi, Giulia; Severi, Francesco; Sala, Cesare; Mattiuz, Giorgio; Conticello, Silvestro G. - In: GENOME BIOLOGY. - ISSN 1474-760X. - ELETTRONICO. - 15:(2014), pp. 0-0. [10.1186/s13059-014-0417-z]
The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas
SARACONI, GIULIA;SEVERI, FRANCESCO;SALA, CESARE;MATTIUZ, GIORGIO;
2014
Abstract
The AID/APOBECs are deaminases that act on cytosines in a diverse set of pathways and some of them have been linked to the onset of genetic alterations in cancer. Among them, APOBEC1 is the only family member to physiologically target RNA, as the catalytic subunit in the Apolipoprotein B mRNA editing complex. APOBEC1 has been linked to cancer development in mice but its oncogenic mechanisms are not yet well understood.
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