The factor H binding activity of meningococcal fHBP can be uncoupled from its bactericidal sensitivity. NMR studies have identified various amino acid residues involved in the fHBP/fH interaction and one or more of these residues is modified in a fHBP to reduce or eliminate its ability to bind to fH.
Modified meningococcal FHBP polypeptides / Banci, Lucia; Cantini, Francesca; Dragonetti, Sara; Gentile, Maria Antonietta; Veggi, Daniele; Scarselli, Maria; Pizza, Mariagrazia. - (2011).
Modified meningococcal FHBP polypeptides
BANCI, LUCIA;CANTINI, FRANCESCA;DRAGONETTI, SARA;
2011
Abstract
The factor H binding activity of meningococcal fHBP can be uncoupled from its bactericidal sensitivity. NMR studies have identified various amino acid residues involved in the fHBP/fH interaction and one or more of these residues is modified in a fHBP to reduce or eliminate its ability to bind to fH.
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