Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors, associated with highly variable postoperative evolution. The scarcity of reliable PPGL prognostic markers continues to complicate patient management. In this study, we explored genome-wide DNA methylation patterns in the context of PPGL malignancy to identify novel prognostic markers.

DNA Methylation Profiling in Pheochromocytoma and Paraganglioma Reveals Diagnostic and Prognostic Markers / de Cubas, Aguirre A; Korpershoek, Esther; Inglada-Pérez, Lucia; Letouzé, Eric; Currás-Freixes, Maria; Fernández, Agustin F; Comino-Méndez, Iñaki; Schiavi, Francesca; Mancikova, Veronika; Eisenhofer, Graeme; Mannelli, Massimo; Opocher, Guiseppe; Timmers, Henri; Beuschlein, Felix; de Krijger, Ronald; Cascon, Alberto; Rodríguez-Antona, Cristina; Fraga, Mario F; Favier, Judith; Gimenez-Roqueplo, Anne-Paule; Robledo, Mercedes. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - STAMPA. - 21:(2015), pp. 3020-3030. [10.1158/1078-0432.CCR-14-2804]

DNA Methylation Profiling in Pheochromocytoma and Paraganglioma Reveals Diagnostic and Prognostic Markers

MANNELLI, MASSIMO;
2015

Abstract

Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors, associated with highly variable postoperative evolution. The scarcity of reliable PPGL prognostic markers continues to complicate patient management. In this study, we explored genome-wide DNA methylation patterns in the context of PPGL malignancy to identify novel prognostic markers.
2015
21
3020
3030
de Cubas, Aguirre A; Korpershoek, Esther; Inglada-Pérez, Lucia; Letouzé, Eric; Currás-Freixes, Maria; Fernández, Agustin F; Comino-Méndez, Iñaki; Schi...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1007876
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