Lasalocid A (LasNa), a common antibiotic in veterinary medicine, is a polyetheral ionophore, disrupting cation equilibria through the cell wall. By means of circular dichroism (in the UV and in the near-IR), paramagnetic NMR, and with the aid of the program PERSEUS, we determined the solution geometry of the 1:1 Las-Yb3+ complex in CD3CN and CDCl3, following a protocol similar to the one successfully used for the anthracycline-metal adduct. The resulting structure is in full agreement with the expectation of the ligand wrapping around the cation in a horseshoe shape. The oxygen atoms participate in the coordination either through a direct, first sphere, or a longer range interaction.
The solution structure of a lasalocid A metal complex in lipophilic solvents / Ripoli, Silvia; Scarano, Simona; Di Bari, Lorenzo; Salvadori, Piero. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - ELETTRONICO. - 13:(2005), pp. 5181-5188. [10.1016/j.bmc.2005.05.034]
The solution structure of a lasalocid A metal complex in lipophilic solvents
SCARANO, SIMONA;
2005
Abstract
Lasalocid A (LasNa), a common antibiotic in veterinary medicine, is a polyetheral ionophore, disrupting cation equilibria through the cell wall. By means of circular dichroism (in the UV and in the near-IR), paramagnetic NMR, and with the aid of the program PERSEUS, we determined the solution geometry of the 1:1 Las-Yb3+ complex in CD3CN and CDCl3, following a protocol similar to the one successfully used for the anthracycline-metal adduct. The resulting structure is in full agreement with the expectation of the ligand wrapping around the cation in a horseshoe shape. The oxygen atoms participate in the coordination either through a direct, first sphere, or a longer range interaction.
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