Hyponatremia is associated with negative clinical outcomes even when chronic and mild. It is also known that hyponatremia treatment should be appropriately performed, to avoid dramatic consequences possibly leading to death. We have previously demonstrated that chronically low extracellular [Na(+)], independently of reduced osmolality, is associated with signs of neuronal cell distress, possibly involving oxidative stress.
Neuronal distress induced by low extracellular sodium in vitro is partially reverted by the return to normal sodium / Benvenuti, S; Deledda, C; Luciani, P; Giuliani, C; Fibbi, B; Muratori, M; Peri, A. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - STAMPA. - (2016), pp. 177-184. [10.1007/s40618-015-0352-1]
Neuronal distress induced by low extracellular sodium in vitro is partially reverted by the return to normal sodium
BENVENUTI, SUSANNA;LUCIANI, PAOLA;MURATORI, MONICA;PERI, ALESSANDRO
2016
Abstract
Hyponatremia is associated with negative clinical outcomes even when chronic and mild. It is also known that hyponatremia treatment should be appropriately performed, to avoid dramatic consequences possibly leading to death. We have previously demonstrated that chronically low extracellular [Na(+)], independently of reduced osmolality, is associated with signs of neuronal cell distress, possibly involving oxidative stress.File | Dimensione | Formato | |
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