Risk of invasive fungal infection in patients affected by acute promyelocytic leukaemia. A report by the SEIFEM-D registry.

Pagano, L; Stamouli, M; Tumbarello, M; Verga, L; Candoni, A; Cattaneo, C; Nadali, G; Mitra, Me; Mancini, V; Nosari, A; Garzia, Mg; Delia, M; Storti, S; Spadea, A; Caramatti, C; Perriello, V; Sanna, M; Vacca, A; De Paolis, Mr; Potenza, L; Salutari, P; Castagnola, C; Fanci, Rosa; Chierichini, A; Melillo, L; Picardi, M; Facchini, L; Martino, B; Di Blasi, R; Cesarini, M; Offidani, M; Vianelli, N; Caira, M; Lessi, F; Ferrari, A; Venditti, A; Pavone, V; Lo Coco, F; Aversa, F; Busca, A.

doi:doi: 10.1111/bjh.13308

On the basis of this study, APL patients must be considered at lower risk of IFI if treated with differentiation-inducing agents. Taking the substantial cost of prophylactic antifungal treatment and the possible side effects, interaction between azoles and drugs active for the treatment of APL into account, a mould active antifungal prophylaxis could be omitted in APL patients at the ﬁrst induction phase of their treatment.

Risk of invasive fungal infection in patients affected by acute promyelocytic leukaemia. A report by the SEIFEM-D registry / Pagano, L; Stamouli, M; Tumbarello, M; Verga, L; Candoni, A; Cattaneo, C; Nadali, G; Mitra, Me; Mancini, V; Nosari, A; Garzia, Mg; Delia, M; Storti, S; Spadea, A; Caramatti, C; Perriello, V; Sanna, M; Vacca, A; De Paolis, Mr; Potenza, L; Salutari, P; Castagnola, C; Fanci, R; Chierichini, A; Melillo, L; Picardi, M; Facchini, L; Martino, B; Di Blasi, R; Cesarini, M; Offidani, M; Vianelli, N; Caira, M; Lessi, F; Ferrari, A; Venditti, A; Pavone, V; Lo-Coco, F; Aversa, F; Busca, A. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - 170:(2015), pp. 434-439. [doi: 10.1111/bjh.13308]