The achievement of malignant traits in several cancers is associated with tumor microenvironment reactivity. New evidence show that the stress hormone noradrenaline enhances melanoma microenvironment reactivity, mainly acting through β3-adrenoreceptors (β2-ARs), favoring recruitment of cancer-associated fibroblasts, M2-macrophages, bone marrow-derived precursors, These events concur in sustaining a pro-inflammatory and pro-angiogenic milieu, finally boosting melanoma malignancy.
β3-adrenoreceptor and tumor microenvironment: a new hub / Chiarugi, P; Filippi, L. - In: ONCOIMMUNOLOGY. - ISSN 2162-4011. - ELETTRONICO. - 4(11):(2015), pp. 0-0.
β3-adrenoreceptor and tumor microenvironment: a new hub
CHIARUGI, PAOLA;FILIPPI, LUCA
2015
Abstract
The achievement of malignant traits in several cancers is associated with tumor microenvironment reactivity. New evidence show that the stress hormone noradrenaline enhances melanoma microenvironment reactivity, mainly acting through β3-adrenoreceptors (β2-ARs), favoring recruitment of cancer-associated fibroblasts, M2-macrophages, bone marrow-derived precursors, These events concur in sustaining a pro-inflammatory and pro-angiogenic milieu, finally boosting melanoma malignancy.
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